Ridge preservation following tooth extraction using a polylactide and polyglycolide sponge as space filler: a clinical and histological study in humans

Abstract

The results of this study indicate that alveolar bone resorption following tooth extraction may be prevented or reduced by the use of a bioabsorbable synthetic sponge of polylactide-polyglycolide acid. The quality of bone formed seemed to be optimal for dental implant insertion.

Clinical use of the resorbable bioscaffold poly lactic co-glycolic acid (PLGA) in post-extraction socket for maintaining the alveolar height: A prospective study

“…24,26 This copolymer is degraded by hydrolysis and its byproducts are excreted in urine. It can be used as a space filler 10,11,[19][20][21] or a membrane. 2,22,23 In our study, we used PLGA copolymer in the form of scaffolds.…”

“…10 During the first week of the study, no major changes in the alveolar bone height were observed in both case and the control group. However, from 4th week onwards till the 24th week, it was clearly evident from the results that there was significant less bone resorption in cases (0.91 AE 0.14 mm) where a biodegradable, synthetic scaffold of PLGA was inserted following tooth extraction as compared to controls (2.15 AE 0.18 mm).…”

Comparison of Ability of Platelet-rich Fibrin vs CollaPlug in maintaining the Buccal Bone Height of Sockets following Extractions in 20 Patients

“…This was placed into the socket without raising a flap. 11,12 The importance of growth factor in enhancing wound healing has become the focus of research in the present day, as they hasten the healing process. They are osteoinductive unlike the other bone grafts which are osteoconductive and remain unresorbed in the grafted site.…”

Ridge preservation comparing a flap vs. a flapless technique using a demineralized bone matrix allograft plus mineralized particulate allograft and covered with a calcium sulfate barrier.

“…When extraction sockets are left alone and heal without any type of ridge preservation procedure the amount of vital bone present after 4-8 months of healing range from 33-54% with 34-67% of trabecular space , Froum et al 2002, Serino et al 2003. In the canine model performing extraction alone in 9 sockets, Cardaropoli et al (2003) reported only 15% vital bone and 85% trabecular space over 6 months.…”

“…They reported only 1 % vital bone, 42% non-vital bone, and 57% trabecular space. In contrast, Serino et al (2003), in a non-graft study, treated 34 sockets in 32 patients over 6 months with a bioabsorbable polylactide/polyglycolic acid sponge (Fisiograft®) to encourage vascular ingrowth. They reported 67% vital bone and 33% trabecular space.…”