Ridge augmentation using mandibular tori

Barker, D; Walls, A.W.G.; Meechan, J G

doi:10.1038/sj.bdj.4801009

Cited by 26 publications

(11 citation statements)

References 7 publications

(6 reference statements)

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“…Sasaki 22 reported an association between palatal and mandibular tori and chronic phenytoin therapy. Rarely may tori be associated with exostosis 21 , unerupted mandibular canines 11 , sclerosteosis 24 , or parafunctional activity. 4 The presence of either palatal or mandibular tori can obscure the radiographic details of maxillary sinuses and lower premolars and interfere with the construction of removable prostheses.…”

Section: Discussionmentioning

confidence: 99%

Torus Palatinus and Torus Mandibularis in Edentulous Patients

Quran

Al-Dwairi²

2006

The Journal of Contemporary Dental Practice

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Aim:To determine the prevalence of tori in Jordanian edentulous patients, the sex variation in their distribution, and their clinical characteristics.Methods: Three hundred and thirty eight patients were examined in the Prosthodontic Clinic in the Department of Restorative Dentistry at Jordan University of Science and Technology. The location, extent, and clinical presentation of tori were recorded related to the age and sex of patients. Results:The overall prevalence of tori was 13.9%. The prevalence of torus palatinus was 29.8% (14/47), while that of torus mandibularis was significantly higher 42.6%(20/47). Both types of tori were associated with each other in 27.7% of cases (13/47). Conclusions:There was no significant difference in the prevalence of tori between males and females. There seems to be a strong association between mandibular and palatal tori.

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Section: Discussionmentioning

confidence: 99%

Torus Palatinus and Torus Mandibularis in Edentulous Patients

Quran

Al-Dwairi²

2006

The Journal of Contemporary Dental Practice

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“…It has been reported that bone response and remodeling happen under functional stress (Frost 2004; Cortes et al 2014), so MT is frequently observed in patients who have powerful masticatory muscles and parafunctional habits (Eggen 1989; Sirirungrojying and Kerdpon 1999; Sonnier et al 1999). Since MT often is asymptomatic, the treatment is not necessary except for prosthetic needs, autologous bone graft, and functional problems, such as food retention or phonetic disturbances and cancer-phobic patients (Barker et al 2001; Proussaefs 2006).…”

Section: Introductionmentioning

confidence: 99%

Loss of Notch3 Signaling Enhances Osteogenesis of Mesenchymal Stem Cells from Mandibular Torus

et al. 2016

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Mandibular torus (MT) is a common intraoral osseous outgrowth located on the lingual surface of the mandible. Histologic features include hyperplastic bone consisting of mature cortical and trabecular bone. Some theories on the etiology of MT have been postulated, such as genetic factors, masticatory hyperfunction, trauma, and continued growth, but the underlying mechanism remains largely unknown. In this study, we investigated the potential role of mesenchymal stem cells (MSCs) derived from human MT in the pathogenesis of bone outgrowth. We demonstrated that MT harbored a distinct subpopulation of MSCs, with enhanced osteogenic and decreased adipogenic differentiation capacities, as compared with their counterparts from normal jaw bone. The increased osteogenic differentiation of mandibular torus MSCs was associated with the suppression of Notch3 signaling and its downstream target genes, Jag1 and Hey1, and a reciprocal increase in the transcriptional activation of ATF4 and NFATc1 genes. Targeted knockdown of Notch3 expression by transient siRNA transfection promoted the expression of osteogenic transcription factors in normal jaw bone MSCs. Our data suggest that the loss of Notch3 signaling may contribute partly to bone outgrowth in MT, as mediated by enhanced MSC-driven osteogenic differentiation in the jaw bone.

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“…(3) Currently the gold standard method in managing large alveolar ridge defects is an autogenous bone graft. (4,5) Although alveolar defects may be reconstructed using mandibular augmentation techniques via autogenous bone grafts, this is considered a major procedure involving a bone graft technique which causes deformity in the donor site. Furthermore, the unknown rate of bone absorption and the necessity to allow several months for the site of the implant to heal, make grafting a sensitive treatment option.…”

mentioning

confidence: 99%

A comparison between the efficacy of Bio-Oss, hydroxyapatite tricalcium phosphate and combination of mesenchymal stem cells in inducing bone regeneration

Vahabi¹,

Amirizadeh²,

Shokrgozar³

et al. 2012

Biomed J

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Background: Recently, tissue engineering has been introduced as a regenerative treatment for bone defects. There is some evidence showing bone regeneration from mesenchymal stem cells (MSC) loaded on hydroxyapatite β-tricalcium phosphate (HA/TCP) as a scaffold in large defects. This study aimed to compare the quality and quantity of regenerated bone using Bio-Oss, HA/TCP and MSC loaded HA/TCP scaffolds. Methods: Mesenchymal stem cells were aspirated from iliac crest bone marrow after extracting the first, second and third premolars and the first molar in five mature hybrid dogs. The cells were cultured and their osteogenic differentiation potential was evaluated after the third cell passage using Alizarin red staining in experimental conditions. The HA/TCP scaffold (3 x 3 x 3 mm) was loaded with undifferentiated mesenchymal stem cells. Bilateral bone defects were then prepared in the jaws using trephine burs. The defects were randomly filled with HA/TCP, Bio-Oss, or HA/TCP + MSCs. One defect served as a control and was left as an empty cavity. All defects except the control defect were covered with an absorbable membrane. Histological and histomorphometric evaluations were conducted after 6 weeks and data were subjected to analysis of variance (ANOVA) (p < 0.05). Results: The empty cavity demonstrated more bone formation (60.80%) than the HA/TCP (44.93%) and Bio-Oss (40.60%) (p < 0.05) groups. However, the difference from the HA/TCP + MSCs group was not significant (46.38%) (p > 0.05). Conclusion: An MSC-loaded HA/TCP scaffold is a more effective alternative than Bio-OSS or HA/TCP in inducing bone regeneration.

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Ridge augmentation using mandibular tori

Cited by 26 publications

References 7 publications

Torus Palatinus and Torus Mandibularis in Edentulous Patients

Torus Palatinus and Torus Mandibularis in Edentulous Patients

Loss of Notch3 Signaling Enhances Osteogenesis of Mesenchymal Stem Cells from Mandibular Torus

A comparison between the efficacy of Bio-Oss, hydroxyapatite tricalcium phosphate and combination of mesenchymal stem cells in inducing bone regeneration

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