Rictor is required for early B cell development in bone marrow

mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway

“…The frequencies and numbers of CD11b + F4/80 + and CD11b + CD115 + monocytes/macrophages in the spleens, peritoneal cavity, colon, and blood of Rictor-deficient mice were remarkably lower than those found in WT mice, whereas the frequencies and numbers of neutrophils, T cells, and B cells in the spleens of Rictor-deficient mice were similar to those found in WT mice. Although, some studies have demonstrated that Rictor deficiency leads to the developmental restriction of T and B cells by using Mx1-Cre-Rictor flox/flox mice, 23 , 54 the inducible knockout model that is limited to cells that respond to interferon. We observed that the priority changes in myeloid progenitors at the early stage after tamoxifen treatment and within the time that tamoxifen-treated ER-Rictor KO mice showed no obvious growth defects or global appearance abnormality.…”