Richter's Transformation Presenting as an Obstructing Endobronchial Lesion

Milkowski, Deborah A.; Worley, Brian D.; Morris, Michael J.

doi:10.1378/chest.116.3.832

Cited by 19 publications

(4 citation statements)

References 12 publications

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“…Extranodal Richter syndrome has also been reported to occur in the nose (Yamamoto et al , 2004), skin (Novice et al , 1989; Jiménez et al , 1993), face (Kendrick & Schwartz, 1983), bone (Hensel et al , 2004) and bronchus (Milkowski et al , 1999). The endobronchial mass secondary to Richter transformation was responsible for airway obstruction (Milkowski et al , 1999). The patient presented with a recurring lingular pneumonia.…”

Section: Ocular Neurological and Other Extranodal Manifestationsmentioning

confidence: 99%

Richter syndrome: a review of clinical, ocular, neurological and other manifestations

Omoti

2008

Br J Haematol

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Summary Richter syndrome describes the development of high‐grade non‐Hodgkin lymphoma (NHL) or Hodgkin lymphoma in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Richter transformation occurs in 3·3 to 10·6% of patients with CLL. The large cell lymphoma clone occurs by transformation of the original CLL clone in the majority of patients, and as a separate and independent neoplasm in fewer cases. Richter transformation may be triggered by viral infections, such as Epstein‐Barr virus infection, which are common in immunosuppressed patients. Trisomy 12 and chromosome 11 abnormalities, as well as multiple genetic defects, have been described in patients with Richter syndrome. These abnormalities may cause CLL cells to proliferate and, by facilitating the acquisition of new genetic abnormalities, to transform into Richter syndrome cells. Presenting features typically include a rapid clinical deterioration with fever in the absence of infection, progressive lymph node enlargement, and an elevation in serum lactate dehydrogenase. Extranodal Richter syndrome has also been reported to occur in the central nervous system, eye, gastrointestinal system, nose, skin, face, bone and bronchus. The therapeutic options include cytoreductive therapy consisting of chemotherapy and immunotherapy, followed by allogeneic stem cell transplantation as postremission therapy.

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Section: Ocular Neurological and Other Extranodal Manifestationsmentioning

confidence: 99%

Richter syndrome: a review of clinical, ocular, neurological and other manifestations

Omoti

2008

Br J Haematol

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“…Parenchymal involvement in HL is seen in up to 11.6% of the patients. Morphologically, lymphoma can present with a whole spectrum of changes ranging from nodules, mass lesions with or without cavity, endobronchial mass, ground glass opacities, a reticular interstitial pattern with involvement of the interstitial lymphatic system, or consolidation with an air bronchogram [13][14][15]. In the current case, NHL developed on the basis of CLL by RT and presented itself as parenchymal cavitary nodular lesions, which are observed in the lung in particular.…”

Section: Discussionmentioning

confidence: 68%

A rare cause of cavitary lesion in the lung: Richter's transformation

Yıldırım

Kara

Yıldız

et al. 2015

11.2 Pleural and Mediastinal Malignancies

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Richter's transformation (RT) refers to the development of aggressive lymphoma during the course of CLL. Clinically, patients with RT present with an aggressive disease course with rapidly enlarging lymph nodes, hepatosplenomegaly, and elevated serum lactate dehydrogenase levels. But rarely it presents with extra nodal organ involvement at the beginning. Common sites of extra nodal involvement are the gastrointestinal tract, eye, central nervous system, lung, and kidney. We are reporting this case that was presented with RT in the lung involvement diagnosed while researching cavitary lesion etiology.

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“…There are two case reports of endobronchial obstruction secondary to chronic lymphocytic leukemia converting to anaplastic lymphomas. 4 The illustrations provided in the two case reports. Masses may match the description of plastic bronchitis in terms of consistency and histology.…”

Section: Discussionmentioning

confidence: 99%

Plastic bronchitis caused by neoplastic infiltrates in a child

Kuperman

Wexler

Shoseyov

et al. 2006

Pediatric Pulmonology

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We report on a case of a 7-year-old girl admitted for pneumonia not responding to oral antibiotics. During hospitalization, her pulmonary status deteriorated as a result of significant atelectasis. An extensive workup revealed an anaplastic large-cell lymphoma with neoplastic cells, found in both a biopsied lymph node and pleural fluid aspirate. Bronchoscopic examination showed nearly complete obstruction of the left side by bronchial casts composed of tumor cells, fibrin, and necrotic material, consistent with plastic bronchitis. Neoplastic infiltration of the bronchi should be considered in the differential diagnosis of disease entities causing plastic bronchitis in children.

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Richter's Transformation Presenting as an Obstructing Endobronchial Lesion

Cited by 19 publications

References 12 publications

Richter syndrome: a review of clinical, ocular, neurological and other manifestations

Richter syndrome: a review of clinical, ocular, neurological and other manifestations

A rare cause of cavitary lesion in the lung: Richter's transformation

Plastic bronchitis caused by neoplastic infiltrates in a child

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