Richard William Porter

Porter, Barbara A.

doi:10.1038/sj.bdj.2011.959

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S-acylation1

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“…Several suggestions have been made; according to which GPI anchors are targeting lipid rafts, specific intracellular compartments, or the apical membrane of polarized epithelial cells. 82,83 The cholesteryl moiety inserts into the lipid bilayer of the cell membrane, thereby restricting the spatial spread of the mature signal, which subsequently affects the cellular response of tissue. Acting as morphogens, these secreted proteins elicit concentration-dependent responses in cells surrounding a localized site of signal production and release.…”

Section: S-acylationmentioning

confidence: 99%