Rich fatty acids diet of fish and olive oils modifies membrane properties in striatal rat synaptosomes

Morales-Martínez, Adriana; Zamorano-Carrillo, Absalom; Montes, Sergio; El-Hafidi, Mohammed; Sánchez-Mendoza, Alicia; Soria-Castro, Elizabeth; Martínez-Lazcano, Juan Carlos; Martínez-Gopar, Pablo Eliasib; Rı́os, Camilo; Pérez-Severiano, Francisca

doi:10.1080/1028415x.2019.1584692

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…From these sections, the brain areas of interest (SN, striatum, hippocampus, and OB) were dissected and stored at −80 °C until processing. As previously described, the brain tissue was homogenized in 3 mL of 0.9% saline solution to quantify ROS, LP, and nitrites [ 39 , 72 , 73 , 74 ]. In addition, the mitochondrial CI activity was measured in total homogenates of each tissue as previously described [ 75 ].…”

Section: Methodsmentioning

confidence: 99%

Oxidative Stress and Mitochondrial Complex I Dysfunction Correlate with Neurodegeneration in an α-Synucleinopathy Animal Model

Morales-Martínez

Martínez-Gómez

Martínez‐Fong

et al. 2022

IJMS

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The α-synucleinopathies constitute a subset of neurodegenerative disorders, of which Parkinson’s disease (PD) is the most common worldwide, characterized by the accumulation of misfolded α-synuclein in the cytoplasm of neurons, which spreads in a prion-like manner to anatomically interconnected brain areas. However, it is not clear how α-synucleinopathy triggers neurodegeneration. We recently developed a rat model through a single intranigral administration of the neurotoxic β-sitosterol β-D-glucoside (BSSG), which produces α-synucleinopathy. In this model, we aimed to evaluate the temporal pattern of levels in oxidative and nitrosative stress and mitochondrial complex I (CI) dysfunction and how these biochemical parameters are associated with neurodegeneration in different brain areas with α-synucleinopathy (Substantia nigra pars compacta, the striatum, in the hippocampus and the olfactory bulb, where α-syn aggregation spreads). Interestingly, an increase in oxidative stress and mitochondrial CI dysfunction accompanied neurodegeneration in those brain regions. Furthermore, in silico analysis suggests a high-affinity binding site for BSSG with peroxisome proliferator-activated receptors (PPAR) alpha (PPAR-α) and gamma (PPAR-γ). These findings will contribute to elucidating the pathophysiological mechanisms associated with α-synucleinopathies and lead to the identification of new early biomarkers and therapeutic targets.

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Section: Methodsmentioning

confidence: 99%

Oxidative Stress and Mitochondrial Complex I Dysfunction Correlate with Neurodegeneration in an α-Synucleinopathy Animal Model

Morales-Martínez

Martínez-Gómez

Martínez‐Fong

et al. 2022

IJMS

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“…All solvents and chemicals were analytical grades from J. T Baker (Avantor Performance Materials, Central Valley, PA, USA). The data were adjusted to molar concentration and normalized with total protein for tissue samples [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver

et al. 2022

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Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However, the mechanisms of CKD dyslipidemia are not fully understood. The use of curcumin (CUR) in CKD models such as 5/6 nephrectomy (5/6Nx) has shown multiple beneficial effects, so it has been proposed to correct dyslipidemia without side effects. This work aimed to characterize CUR’s potential therapeutic effect on dyslipidemia and alterations in lipid metabolism and mitochondrial ß-oxidation in the liver and kidney in 5/6Nx. Male Wistar rats were subjected to 5/6Nx and progressed by 4 weeks; meanwhile, CUR (120 mg/kg) was administered for weeks 5 to 8. Our results showed that CUR reversed the increase in liver and kidney damage and hypertriglyceridemia induced by 5/6Nx. CUR also reversed mitochondrial membrane depolarization and β-oxidation disorders in the kidney and the increased lipid uptake and the high levels of proteins involved in fatty acid synthesis in the liver and kidney. CUR also decreased lipogenesis and increased mitochondrial biogenesis markers in the liver. Therefore, we concluded that the therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia is associated with the restoration of renal mitochondrial ß-oxidation and the reduction in lipid synthesis and uptake in the kidneys and liver.

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“…In calculating this new index, the intake of most fatty acids and their melting points, which indicate the fluidity of fatty acids and their quality, are considered [ 9 ]. Melting points and quantity of dietary fats affect the lipid composition of membrane phospholipids and, consequently, membrane fluidity [ 10 , 11 ]. Melting points increase with increasing chain length and level of saturation of fatty acid, leading to decreased cell membrane fluidity [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The relationship between dietary lipophilic index and load with depression, anxiety, and stress symptoms

Barzegaran,

Jazayeri,

Abolghasemi

et al. 2023

BMC Psychiatry

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Background Dietary fatty acids can affect brain health by modifying neuronal membrane fluidity. Dietary lipophilic index (LI) and load (LL) may be related to cell membrane fluidity. This study aimed to determine the relationship between dietary LI and LL with symptoms of depression, anxiety and stress. Methods In this cross-sectional study, taken from the YaHS (Yazd Health Study) population-based cohort, the data of 2,982 individuals was extracted. Several questionnaires- a 178-item Food Frequency Questionnaire (FFQ), Depression, Anxiety and Stress Scale 21 (DASS 21), and International Physical Activity Questionnaire (IPAQ)- were used to obtain information on dietary intake, mental status, and physical activity, respectively. LI and LL were calculated using dietary intake and the melting point of each fatty acid. Results The analysis was performed on 2982 individuals. The odds ratio of depression in the second tertile of dietary LI compared to the first tertile was 0.815 (95% CI 0.66–1.00, P = 0.051, Ptrend = 0.017) and after adjusting confounders was 0.793 (95% CI 0.63–0.99, P = 0.043, Ptrend = 0.011). Also, LL was related inversely with anxiety (0.771, 95% CI 0.63–0.93, P = 0.003) that after multiple regression, OR of anxiety was 0.762 (95% CI 0.53–1.07, P = 0.045). The odds of stress in the third tertile of LL was 1.064 but not statistically significant (95% CI 0.88–1.28, P = 0.729). Conclusion This study showed an inverse association between dietary LI and depression symptoms. Anxiety and stress did not show a significant relationship with LI or LL.

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Rich fatty acids diet of fish and olive oils modifies membrane properties in striatal rat synaptosomes

Cited by 5 publications

References 48 publications

Oxidative Stress and Mitochondrial Complex I Dysfunction Correlate with Neurodegeneration in an α-Synucleinopathy Animal Model

Oxidative Stress and Mitochondrial Complex I Dysfunction Correlate with Neurodegeneration in an α-Synucleinopathy Animal Model

Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver

The relationship between dietary lipophilic index and load with depression, anxiety, and stress symptoms

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