Rice flour fermented with Lactobacillus paracasei CBA L74 in the treatment of atopic dermatitis in infants: A randomized, double- blind, placebo- controlled trial

D’Auria, Enza; Panelli, Simona; Lunardon, Luisa; Pajoro, Massimo; Paradiso, Laura; Beretta, Silvia; Loretelli, Cristian; Tosi, Diego; Perini, Matteo; Bedogni, Giorgio; Abdel-Salam, A. F.; Fiorina, Paolo; Bandi, Claudio; Zuccotti, Gian Vincenzo

doi:10.1016/j.phrs.2020.105284

Cited by 23 publications

(32 citation statements)

References 45 publications

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“…Additionally, heat-killed L. paracasei CBA L74 has a minimal effect on steroid use, but its effect on reducing the severity of AD needs to be further studied ( D'Auria et al., 2021 ). However, there is no evidence that L. paracasei GM-080 has a retention effect equivalent to that of glucocorticoids ( Yan et al., 2019 ).…”

Section: Monostrain Lactobacillus In the Treatment...mentioning

confidence: 99%

Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence

Xie

Chen

et al. 2023

Front. Cell. Infect. Microbiol.

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Atopic dermatitis (AD) is a chronic inflammatory skin disease, accompanied by itching and swelling. The main pathological mechanism of AD is related to the imbalance between Type 2 helper cells (Th2 cells) and Type 1 helper cells (Th1 cells). Currently, no safe and effective means to treat and prevent AD are available; moreover, some treatments have side effects. Probiotics, such as some strains of Lactobacillus, can address these concerns via various pathways: i) facilitating high patient compliance; ii) regulating Th1/Th2 balance, increasing IL-10 secretion, and reducing inflammatory cytokines; iii) accelerating the maturation of the immune system, maintaining intestinal homeostasis, and improving gut microbiota; and iv) improving the symptoms of AD. This review describes the treatment and prevention of AD using 13 species of Lactobacillus. AD is commonly observed in children. Therefore, the review includes a higher proportion of studies on AD in children and fewer in adolescents and adults. However, there are also some strains that do not improve the symptoms of AD and even worsen allergies in children. In addition, a subset of the genus Lactobacillus that can prevent and relieve AD has been identified in vitro. Therefore, future studies should include more in vivo studies and randomized controlled clinical trials. Given the advantages and disadvantages mentioned above, further research in this area is urgently required.

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Section: Monostrain Lactobacillus In the Treatment...mentioning

confidence: 99%

Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence

Xie

Chen

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Currently, the term “postbiotic” refers to soluble components with biological activity that could be a safer alternative to the use of whole bacteria [ 208 ]. Very few studies have investigated the role of postbiotics in AD in adults [ 209 ] and in children with promising results [ 210 , 211 ], but research in this field is still in its infancy. New confirmation about the role of probiotic (prebiotics and postbiotics) therapy is needed, and it is important to better define other factors, such as which disease can benefit most, the most efficient bacterial combination, the optimal dosage, and the duration of the treatment.…”

Section: Topical and Oral Probiotics In Skin Health And Diseases: State Of The Artmentioning

confidence: 99%

A Journey on the Skin Microbiome: Pitfalls and Opportunities

Pistone

Meroni

Panelli

et al. 2021

IJMS

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The human skin microbiota is essential for maintaining homeostasis and ensuring barrier functions. Over the years, the characterization of its composition and taxonomic diversity has reached outstanding goals, with more than 10 million bacterial genes collected and cataloged. Nevertheless, the study of the skin microbiota presents specific challenges that need to be addressed in study design. Benchmarking procedures and reproducible and robust analysis workflows for increasing comparability among studies are required. For various reasons and because of specific technical problems, these issues have been investigated in gut microbiota studies, but they have been largely overlooked for skin microbiota. After a short description of the skin microbiota, the review tackles methodological aspects and their pitfalls, covering NGS approaches and high throughput culture-based techniques. Recent insights into the “core” and “transient” types of skin microbiota and how the manipulation of these communities can prevent or combat skin diseases are also covered. Finally, this review includes an overview of the main dermatological diseases, the changes in the microbiota composition associated with them, and the recommended skin sampling procedures. The last section focuses on topical and oral probiotics to improve and maintain skin health, considering their possible applications for skin diseases.

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“…1 Recent studies show increasing interest in the potential clinical application of postbiotics to prevent and treat AD. [5][6][7][8][9][10][11][12][13] Postbiotics are defined as "preparations of inanimate microorganisms and/or their components that confer a health benefit on the host". 14 Aside from mutually benefiting hosts, another similarity between probiotics and postbiotics is their high strain-specificity.…”

Section: Introductionmentioning

confidence: 99%

Next-Gen Biotherapeutics: A Systematic Review and Network Meta-Analysis on Postbiotics as Treatment For Pediatric Atopic Dermatitis

Sajo

Tan‐Lim

Orteza

et al. 2023

Preprint

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Background: Due to the recency of the postbiotic field, there are no head-to-head postbiotic studies investigating its biotherapeutic potential for atopic dermatitis (AD). No network meta-analysis (NMA) has yet been conducted to synthesize relevant studies to compare postbiotic interventions for AD. Objective: To assess the comparative efficacy and safety of postbiotic strains for treating pediatric AD. Methodology: This is an NMA of randomized controlled studies that evaluate postbiotics in treating pediatric AD. Systematic search of databases and registers from inception to November 30, 2022. Three authors independently performed the search, screening, appraisal using the Cochrane risk of bias tool version 2 and data extraction. Data analysis was done using STATA14 software. Results: There were 9 studies that evaluated 8 postbiotic preparations. Lactobacillus rhamnosus IDCC 3201 (LR) ranked highest in the efficacy outcome. Compared to placebo, LR may be effective in reducing symptoms of atopic dermatitis both in the main analysis (SMD -0.53, 95%CI -1.02 to -0.04) and sensitivity analysis involving studies that used SCORAD (MD -5.52, 95% CI -10.46 to -0.58), based on low-certainty evidence. Based on moderate-certainty evidence, LR probably does not increase the risk of adverse events (RR 0.97, 95% CI 0.79 to 1.21). Although Lactobacillus paracasei GM080 (LP2) ranked highest in the safety outcome, it may not reduce AD symptoms compared to placebo (SMD -0.03, 95% CI -0.37 to 0.32) based on low-certainty evidence. Conclusion: LR showed significant benefits for children with AD, based on low-certainty evidence. Further investigation on LR is recommended.

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Rice flour fermented with Lactobacillus paracasei CBA L74 in the treatment of atopic dermatitis in infants: A randomized, double- blind, placebo- controlled trial

Cited by 23 publications

References 45 publications

Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence

Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence

A Journey on the Skin Microbiome: Pitfalls and Opportunities

Next-Gen Biotherapeutics: A Systematic Review and Network Meta-Analysis on Postbiotics as Treatment For Pediatric Atopic Dermatitis

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