Rice consumption and predisposition to metabolic diseases: The role of PPARγ and GLUT4 dysregulation

Abubakar, Bilyaminu; Ismail, Norsharina; Omar, Abdul Rahman; Bakar, Zuki Abu; Ismail, Maznah

doi:10.1016/j.jnim.2017.11.001

Cited by 2 publications

(2 citation statements)

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“…In this study, fruit fly consumption of WR appeared to promote fat expansion, weight gain, higher oxidised LDL levels, and elevated oxidative stress that were observed. Similar observations were also made by [ 11 ], who reported enhanced body weight gain in rats fed on WR. The reduced body weight seen in the BR groups can be attributed to the multiple bioactive compounds in the BR cultivars.…”

Section: Discussionsupporting

confidence: 89%

“…WR is a staple food in many low- and middle-income countries (LMICs) facing rapid economic development and nutritional transition [ 8 ]. Consumption of WR as a staple food predisposes individuals to metabolic disorders, mostly as a result of loss of important bioactive compounds to the polishing processes [ 9 , 10 , 11 , 12 ]. Regular consumption of WR has been implicated in fat store expansion, which promotes higher weight gain, oxidized low density lipoprotein (ox-LDL) levels and worsening of lipid metabolism in rats as a result of a conversion of excess glucose to free fatty acids (FFAs) and triglycerides (TGs) [ 10 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model

et al. 2023

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Consumption of white rice (WR) has been shown to predispose individuals to metabolic disorders. However, brown rice (BR), which is relatively richer in bioactive compounds, possesses anti-glycaemic and antioxidant effects. In this study, fifteen cultivars of paddy rice that are predominantly consumed in North West Nigeria were analysed for their nutritional composition, bioactive contents and effects on metabolic outcomes in a fruit fly model. Gene expression analyses were conducted on the whole fly, targeting dPEPCK, dIRS, and dACC. The protein, carbohydrate, and fibre contents and bioactives of all BR cultivars were significantly different (p < 0.05) from the WR cultivars. Moreover, it was demonstrated that the glucose and trehalose levels were significantly higher (p < 0.05), while glycogen was significantly lower (p < 0.05) in the WR groups compared to the BR groups. Similarly, the expression of dACC and dPEPCK was upregulated, while that of dIRS was downregulated in the WR groups compared to the BR groups. Sex differences (p < 0.05) were observed in the WR groups in relation to the nutrigenomic effects. Our findings confirm metabolic perturbations in fruit flies following consumption of WR via distortion of insulin signalling and activation of glycogenolysis and gluconeogenesis. BR prevented these metabolic changes possibly due to its richer nutritional composition.

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Section: Discussionsupporting

confidence: 89%