Rice Bran Fermented with Kimchi-Derived Lactic Acid Bacteria Prevents Metabolic Complications in Mice on a High-Fat and -Cholesterol Diet

Abstract

This aim of this study was to investigate the potential beneficial effects of rice bran powder, fermented by Weissella koreensis DB1 isolated from kimchi, to protect against obesity and dyslipidemia induced by a high-fat and high-cholesterol diet, in a mouse model. Male mice were fed a modified AIN-93M diet containing high fat/high-cholesterol (HFCD), or same diet supplemented with non-fermented rice bran powder (HFCD-RB) or fermented rice bran powder (HFCD-FRB) for 10 weeks. In the HFCD-FRB group, body weight, liver and white fat pads weights, triglyceride (TG), total cholesterol (TC), non-high-density lipopreotein cholesterol (non-HDL-C), insulin, glucose and leptine levels in serum, TG levels and the ratio of fat droplets in the liver, TG levels and fat cell size in adipose tissue were decreased, and (high-density lipopreotein cholesterol) HDL-C and adiponectin levels in serum were increased, compared with the HFCD group. The HFCD-FRB group had significantly lower CCAAT-enhancer-binding potein α (C/EBPα), sterol regulatory element-binding transcription protein-1c (SREBP-1c), fatty acid synthase (FAS), and acetyl CoA carboxylase (ACC) gene expression when compared to the HFCD group. The anti-obesity and hypolipidemic effects were marginally greater in the HFCD-FRB group than in the HFCD-RB group. These results suggest that fermented rice bran powder by Weissella koreensis DB1 may have potential beneficial effects on the obesity-related abnormalities and the dysfunction of lipid metabolism.

Effects of the Water Extract of Fermented Rice Bran on Liver Damage and Intestinal Injury in Aged Rats with High-Fat Diet Feeding

“…Lipid accumulation was also improved by FRB treatment in IR-HepG2 cells [ 35 ]. In a mouse model of obesity, it was reported that supplementation with FRB could decrease fatty depositions in liver tissues [ 36 ]. Another study showed that the inflammatory reactions were inhibited after FRB treatment by suppressing the mRNA levels of TNF-α and IL-6 in RBL-2H3 cells [ 37 ].…”

“…It was pointed out that hypoadiponectinemia and higher levels of serum leptin commonly occurred in NASH patients [ 9 ]. Increased serum leptin levels and decreased serum adiponectin levels were also observed in mice fed a HF diet for 10 weeks [ 36 ]. In addition, SIRT1 and AMPK were indicated to suppress lipogenesis through inhibition of SREBP-1 levels and also activation of FA oxidation via PPARα in the liver [ 39 ].…”

“…Previous studies suggested that FRB exerted anti-obesity and anti-dyslipidemic effects on HF diet-fed mice [ 36 ] and rats [ 41 ]. Alauddin et al reported that FRB could improve IR, decrease the serum leptin/adiponectin ratio, and activate the liver AMPK signaling pathway in stroke-prone spontaneously hypertensive rats [ 25 ].…”

Probiotic Fermented Feed Alleviates Liver Fat Deposition in Shaoxing Ducks via Modulating Gut Microbiota

“…Fermented products, which provided live microbial, have been commonly applied in the human and poultry industry (Li et al, 2020 ; Park et al, 2021 ; Wu et al, 2021 ; Lv et al, 2022 ). Rice bran fermented by Weissella koreensis DB1 can decrease the serum levels of triglyceride (TG) and total cholesterol (TC) and significantly downregulate the hepatic gene expression of C/EBP, SREBP-1c, FAS, and ACC in mice (Park et al, 2021 ).…”

“…Fermented products, which provided live microbial, have been commonly applied in the human and poultry industry (Li et al, 2020 ; Park et al, 2021 ; Wu et al, 2021 ; Lv et al, 2022 ). Rice bran fermented by Weissella koreensis DB1 can decrease the serum levels of triglyceride (TG) and total cholesterol (TC) and significantly downregulate the hepatic gene expression of C/EBP, SREBP-1c, FAS, and ACC in mice (Park et al, 2021 ). Meanwhile, many in vitro fermentation studies have shown that fermented feed can improve poultry egg performance, immune function, intestinal development, and lipid metabolism (Engberg et al, 2009 ; Gao et al, 2009 ; Olukomaiya et al, 2019 ; Sugiharto and Ranjitkar, 2019 ; Saleh et al, 2021 ).…”