Rice bran extract prevents the elevation of plasma peroxylipid in KKAy diabetic mice

Kanaya, Yumi; Doi, Takuya; Sasaki, Hideyuki; Fujita, Atsuyo; Matsuno, Shohei; Okamoto, K.; Nakano, Yuuko; Tsujiwaki, Satomi; Furuta, Hiroto; Nishi, Masahiro; Tsuno, Takuo; Taniguchi, Hiroya; Nanjo, Kishio

doi:10.1016/j.diabres.2003.09.021

Cited by 36 publications

(18 citation statements)

References 5 publications

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“…Rice bran contains lots of proteins, minerals, amino acids [1], lipase [2], and various antioxidant compounds, such as polyphenols [3], ferulic acids [3], γ-oryzanols [4], tocopherols, and tocotrienols [5]. Due to the antioxidant ability inhibiting the production of reactive oxygen species, rice bran has recently obtained much attention as a natural source of health food related to diabetes [6], atherosclerosis [7], and cancer [8].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, antibacterial, tyrosinase inhibitory, and biofilm inhibitory activities of fermented rice bran broth with effective microorganisms

Lee

Cho

2010

Biotechnol Bioproc E

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The effective microorganism fermentation extract (EM-X) is a refreshment beverage widely consumed in East Asia. Due to the antioxidant property of the health beverage, EM-X has potential benefits for the human immune system and has been generally accepted in clinical practice. In search of new functions of EM-X, another version of EM-X, named EM-YU in this study, which is fermented from rice bran, seaweed, and kiwifruit with effective microorganisms demonstrates high antioxidant, antibacterial, tyrosinase inhibition activities, and biofilm inhibition activity of pathogenic bacteria. The antioxidant activity of 1.8% EM-YU was equivalent to that of 0.01 mg/mL vitamin C. Also, EM-YU clearly inhibited the cell growth of two pathogenic bacteria, bëÅÜÉêáÅÜá~=Åçäá=O157:H7 and mëÉìÇçãçå~ë=~ÉêìÖáåçë~ PAO1; and EM-YU broth (6.7%) inhibited (55 ± 1%) the activity of mushroom tyrosinase. Moreover, the ethyl acetate extract of EM-YU, called EM-YU-EX (0.6 mg/mL), 7-fold reduced the biofilm formation of bK=Åçäá=O157:H7 without affecting its cell growth. It is the first report that EM-X variant possess antibacterial, tyrosinase inhibitory, and biofilm inhibitory activities. These results support other beneficial properties of the natural health product EM-X variant (EM-YU). © KSBB hÉóïçêÇëW=êáÅÉ=Äê~åI=ÉÑÑÉÅíáîÉ=ãáÅêççêÖ~åáëãëI=~åíáçñáÇ~åíI=~åíáÄ~ÅíÉêá~äI=íóêçëáå~ëÉI=ÄáçÑáäã= = = = =

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Section: Introductionmentioning

confidence: 99%

Antioxidant, antibacterial, tyrosinase inhibitory, and biofilm inhibitory activities of fermented rice bran broth with effective microorganisms

Lee

Cho

2010

Biotechnol Bioproc E

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“…Previous studies investigating the antioxidative effect of rice bran T3 have been found in rats under conditions such as diabetes mellitus 15) and hyperlipidemia. 16) We measured the PL-OOH and TBARS concentrations as indices of lipid peroxidation in rats fed with a rice bran T3 concentrate under physiological conditions, but not pathological conditions.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12] These studies used palm T3, which has an abundance of -and -T3; however, the distribution of rice bran T3 (rich in -T3) has not been examined. Rice bran T3 has been shown to have anti-hypercholesterolemic, 13) anticancer, 14) and antioxidative 15,16) activities. In this study, we orally administered tocotrienol-rich fraction prepared from rice bran (RBT3) to rats, and examined the distribution of T3 in the rat tissues.…”

mentioning

confidence: 99%

Distribution of Tocotrienols in Rats Fed a Rice Bran Tocotrienol Concentrate

Kawakami

Tsuzuki

Nakagawa

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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“…We have previously reported that RT had a protective effect against oxidative damage in an experiment with diabetic mice 15 . Therefore, RT might have a beneficial effect for the prevention of adipocytokine abnormalities and fatty liver.…”

Section: Introductionmentioning

confidence: 94%

Effect of anti-oxidants, Ricetrienol and α-tocopherol, on adipocytokine abnormalities and fatty liver in Otsuka Long-Evans Tokushima Fatty diabetic rats

Tatsumi

Sasaki

Fujita

et al. 2010

Journal of Diabetes Investigation

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Introduction: We investigated the effect of Ricetrienol, which is an anti‐oxidant extracted from rice bran, and α‐tocopherol on the adipocytokine abnormalities and fatty liver in Otsuka Long‐Evans Tokushima Fatty (OLETF) rats.Materials and Methods: A total of 18 OLETF rats were bred using a 30% sucrose solution (the diabetic group; DM), whereas another 18 OLETF rats were bred using ordinary water (the non‐diabetic obese group; OB) as drinking water, respectively. After the sucrose‐fed rats developed diabetes, all of the rats from the diabetic and obese groups were randomly divided into three groups. Then each group was fed either standard chow (DM‐S, OB‐S group), 0.05% Ricetrienol‐containing chow (DM‐R, OB‐R group) or 0.05%α‐tocopherol‐containing chow (DM‐A, OB‐A group), respectively. After 12 weeks of feeding, all the rats were killed. Plasma insulin, adiponectin, resistin and leptin were assayed by enzyme immunoassay. Histopathological findings of liver tissue were scored according to Brunt and Kleiner’s method, and triglyceride contents of the liver tissue were investigated.Results: Plasma adiponectin was significantly reduced in DM‐S compared with OB‐S, but it had significantly increased in DM‐R and DM‐A as opposed to DM‐S. Plasma resistin showed a significant increase in DM‐S compared with OB‐S, but it was significantly reduced in DM‐A than in DM‐S. Though the triglyceride contents of liver tissue significantly increased in DM‐S as opposed to OB‐S, they were significantly reduced in DM‐R compared with DM‐S. Histopathological scores were significantly higher in DM‐S than OB‐S.Conclusions: The present study shows that Ricetrienol might prevent adipocytokine abnormalities and fatty liver in OLETF diabetic rats. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00090.x, 2011)

show abstract

Rice bran extract prevents the elevation of plasma peroxylipid in KKAy diabetic mice

Cited by 36 publications

References 5 publications

Antioxidant, antibacterial, tyrosinase inhibitory, and biofilm inhibitory activities of fermented rice bran broth with effective microorganisms

Antioxidant, antibacterial, tyrosinase inhibitory, and biofilm inhibitory activities of fermented rice bran broth with effective microorganisms

Distribution of Tocotrienols in Rats Fed a Rice Bran Tocotrienol Concentrate

Effect of anti-oxidants, Ricetrienol and α-tocopherol, on adipocytokine abnormalities and fatty liver in Otsuka Long-Evans Tokushima Fatty diabetic rats

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