Rice bran extract mitigates depressive-like behavior in dextran sulfate sodium-induced colitis: Involvement of the gut-brain axis and Sirt1 signaling pathway

Shendy, Hagar M.; Mohamed, Sarah S.; Abd El-Haleim, Enas A.; Galal, Omneya; Wadie, Walaa; Helal, Amr; Khayyal, Mohamed T.

doi:10.1016/j.fct.2023.114386

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2024

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Cited by 4 publications

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Ameliorating Effect of Standardized Rice Bran Supplement on Depressive-Like Behaviors in Ovariectomized Mice

Kim,

Cho,

Lee

et al. 2024

Journal of Medicinal Food

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Ameliorating Effect of Standardized Rice Bran Supplement on Depressive-Like Behaviors in Ovariectomized Mice

Kim,

Cho,

Lee

et al. 2024

Journal of Medicinal Food

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Chinese bayberry extract regulates the permeability of blood–cerebrospinal fluid barrier and ameliorates experimental colitis-related brain comorbidities in mice

Huang,

Yan,

Liu

et al. 2024

Food Quality and Safety

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Objectives The anxiety, depression symptoms, and cognitive decline related to inflammatory bowel disease (IBD) are recognized to have an impact on patients’ health. The blood-cerebrospinal fluid barrier (BCSFB) is important in somatic disease-related psychiatric and cognitive disorders, however, few treatments show efficacy. The objective of this research was to seek the protective effect of Chinese bayberry extract on inflammatory bowel disease-related brain comorbidities. Materials and Methods C57BL/6J mice were induced with dextran sulfate sodium (DSS) solution to establish the experimental model, followed by the administration of Chinese bayberry extract. Oxidative stress indexes, immunofluorescence of choroid plexus, and BCSFB permeability were further investigated. Results Chinese bayberry extract improved behavioral markers and reduced the level of oxidative stress in the brain. In addition, administration of the bayberry extract increased the tight junction proteins in the choroid plexus and a significant decrease in the permeability of the BCSFB. Conclusions Chinese bayberry extract has the potential therapeutic effect of relieving inflammatory bowel disease-related brain comorbidities. The underlying mechanism is associated with a decrease in oxidative stress in the brain and a decrease in the permeability of the BCSFB.

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The modulatory influence of humic acid on cognitive impairment and neurobehavioral changes induced by colitis in adult male Wistar rats

Omolaso,

Ogunmiluyi,

Adeniran

et al. 2024

Nutrire

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Rice bran extract mitigates depressive-like behavior in dextran sulfate sodium-induced colitis: Involvement of the gut-brain axis and Sirt1 signaling pathway

Cited by 4 publications

References 35 publications

Ameliorating Effect of Standardized Rice Bran Supplement on Depressive-Like Behaviors in Ovariectomized Mice

Ameliorating Effect of Standardized Rice Bran Supplement on Depressive-Like Behaviors in Ovariectomized Mice

Chinese bayberry extract regulates the permeability of blood–cerebrospinal fluid barrier and ameliorates experimental colitis-related brain comorbidities in mice

The modulatory influence of humic acid on cognitive impairment and neurobehavioral changes induced by colitis in adult male Wistar rats

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