Rice bran ameliorated DSS-induced colitis by suppressing inflammation and modulating gut microbiota

Abstract

Globally, the incidence of colitis is on the rise. Rice bran (RB) is a promising natural dietary supplement. The research aimed to explore how RB impacts colitis in mice caused by dextran sulfate sodium. Notably, administering RB led to better weight control, better colon lengths, and a decreased disease activity index. Furthermore, it was discovered that RB boosts antioxidant abilities, elevates short-chain fatty acids concentrations, fortifies the intestinal mucosal barrier, lowers histopathology scores, and suppresses inflammation. The Ileibacterium vane's relative abundance was greater in colitis mice. Administering RB led to a reduction in the comparative abundance of Ileibacterium vans and exhibited an increased abundance of Akkermansia muciniphila. These findings provide a scientific basis for the development of RB as a natural dietary supplement to improve gut microbiota dysbiosis and enhance the comprehensive utilization value of RB.