Ribosome, Chemistry of

Abstract

Ribosomes are the most complex, ancient, and important RNA‐protein complexes present in every cell. A large body of previous data shows that their function is carefully regulated and quality controlled, which leads to a remarkably low rate of amino‐acid misincorporation. A prerequisite to this exquisitely accurate function is correctly assembled ribosomes. Here, I consider mechanisms that may help in regulating ribosome assembly and in ensuring that ribosomes are faithfully assembled. Evidence for the existence of these mechanisms is then presented based on data in the literature. Future experiments will be required to test the importance of these events in quality control.

Background Effective Action with Nonlinear Massive Gauge Fixing

“…By contrast, the effective action generates 1PI correlators by construction. In the background formalism, the difference between the Schwinger functional and the effective action on the level of 1PR diagrams can also be constructed to higher-loop orders [95][96][97][98][99].…”