Ribosomal subunit antiassociation activity in rabbit reticulocyte lysates. Evidence for a low molecular weight ribosomal subunit antiassociation protein factor (Mr = 25,000).

Rice OseIF6.1 encodes a eukaryotic translation initiation factor and is essential for the development of grain and anther

“…By binding to the 60S ribosome subunit, eIF6 prevents its association with the 40S ribosome subunit ( Russell and Spremulli, 1980 ). Homologous proteins of wheat eIF6 were subsequently isolated and purified from various sources, including rabbit ( Raychaudhuri et al., 1984 ), calf, human ( Si et al., 1997 ), yeast ( Si and Maitra, 1999 ), and Arabidopsis ( Kato et al., 2010 ). The phylogenetic analysis indicates that the eIF6 protein is conserved among eukaryotes ( Figure 1A ).…”

Eukaryotic initiation factor 6 repression mitigates atherosclerosis progression by inhibiting macrophages expressing Fasn

“…Eukaryotic translation initiation factor 6 (Eif6), formed by five stretches of quasi‐identical α/β subdomains, is an evolutionarily conserved rigid protein with a cavity that contains 16 well‐ordered water molecules with a limited degree of motility 15,16 . Eif6 prevents the interaction of 40 S ribosomal subunits with 60 S subunits through its binding to 60 S ribosomes 17,18 . Cytoplasmic Eif6 functions as an initiation factor to mediate translation downstream from growth factors, while nucleolar Eif6 is a component of the pre‐ribosomal particles and is required for the biogenesis of 60 S subunits 19 …”

“…15,16 Eif6 prevents the interaction of 40 S ribosomal subunits with 60 S subunits through its binding to 60 S ribosomes. 17,18 Cytoplasmic Eif6 functions as an initiation factor to mediate translation downstream from growth factors, while nucleolar Eif6 is a component of the pre-ribosomal particles and is required for the biogenesis of 60 S subunits. 19 Eif6 is widely expressed in fibroblasts, smooth muscle cells, epidermal cells, epithelial cells, and macrophages.…”