Ribosomal dimerization factor YfiA is the major protein synthesized after abrupt glucose depletion in Lactococcus lactis

Breüner, Anne; Frees, Dorte; Varmanen, Pekka; Boguta, Anna Monika; Hammer, Karin; Martinussen, Jan; Kilstrup, Mogens

doi:10.1099/mic.0.000362

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…When not in use, ribosomes are stored as 100S complexes. The ribosome dimerization factor YfiA is highly expressed during slow growth periods such as stationary phase (Puri et al 2014;Bre üner et al 2016).…”

Section: Systems Biologymentioning

confidence: 99%

The Evolution of gene regulation research in Lactococcus lactis

Gijtenbeek

Jong

Meulen

et al. 2017

FEMS Microbiology Reviews

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Lactococcus lactis is a major microbe. This lactic acid bacterium (LAB) is used worldwide in the production of safe, healthy, tasteful and nutritious milk fermentation products. Its huge industrial importance has led to an explosion of research on the organism, particularly since the early 1970s. The upsurge in the research on L. lactis coincided not accidentally with the advent of recombinant DNA technology in these years. The development of methods to take out and re-introduce DNA in L. lactis, to clone genes and to mutate the chromosome in a targeted way, to control (over)expression of proteins and, ultimately, the availability of the nucleotide sequence of its genome and the use of that information in transcriptomics and proteomics research have enabled to peek deep into the functioning of the organism. Among many other things, this has provided an unprecedented view of the major gene regulatory pathways involved in nitrogen and carbon metabolism and their overlap, and has led to the blossoming of the field of L. lactis systems biology. All of these advances have made L. lactis the paradigm of the LAB. This review will deal with the exciting path along which the research on the genetics of and gene regulation in L. lactis has trodden.

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Section: Systems Biologymentioning

confidence: 99%

The Evolution of gene regulation research in Lactococcus lactis

Gijtenbeek

Jong

Meulen

et al. 2017

FEMS Microbiology Reviews

View full text Add to dashboard Cite

show abstract

Ribosome Hibernation

et al. 2018

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Protein synthesis consumes a large fraction of available resources in the cell. When bacteria encounter unfavorable conditions and cease to grow, specialized mechanisms are in place to ensure the overall reduction of costly protein synthesis while maintaining a basal level of translation. A number of ribosome-associated factors are involved in this regulation; some confer an inactive, hibernating state of the ribosome in the form of 70S monomers (RaiA; this and the following are based on Escherichia coli nomenclature) or 100S dimers (RMF and HPF homologs), and others inhibit translation at different stages in the translation cycle (RsfS, YqjD and paralogs, SRA, and EttA). Stationary phase cells therefore exhibit a complex array of different ribosome subpopulations that adjusts the translational capacity of the cell to the encountered conditions and ensures efficient reactivation of translation when conditions improve. Here, we review the current state of research regarding stationary phase-specific translation factors, in particular ribosome hibernation factors and other forms of translational regulation in response to stress conditions.

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Ribosomal dimerization factor YfiA is the major protein synthesized after abrupt glucose depletion in Lactococcus lactis

Cited by 2 publications

References 46 publications

The Evolution of gene regulation research in Lactococcus lactis

The Evolution of gene regulation research in Lactococcus lactis

Ribosome Hibernation

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