Ribose Found in the Gas Phase

Cocinero, Emilio J.; Lesarri, Alberto; Écija, Patricia; Basterretxea, Francisco J.; Grabow, Jens‐Uwe; Fernández, José A.; Castaño, Fernando

doi:10.1002/ange.201107973

Cited by 38 publications

(45 citation statements)

References 56 publications

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“…[21,[28][29][30][31] As ingle conformer has been predicted for exo-2,3-epoxynorbornane, as expected from the steric constraints present in the bridged bicyclem otif. This conformer was optimized with the Møller-Plesset perturbation (MP2) and density functional theory (B3LYP and M06-2X functionals).…”

Section: Theoretical Calculationsmentioning

confidence: 90%

“…The structures of the most stable conformers were characterized and determined by Fourier transform microwave Spectroscopy (FTMW), which provides the most accurate view of the molecular structure through the measurement of the moments of inertia. Conformers, [21] tautomers, [22] isotopologues, [23] and enantiomers [24] can be distinguished unambiguously as independents pecies by using this spectroscopict echnique. In the present paper,w ei ncrease the knowledge on the structurea nd spectroscopy of molecules with bridged bicyclic rings by studying exo-2,3-epoxynorbornane (Figure 1), which is the simplest molecule in which the influence of the epoxy group on the norbornane ring can be discerned.…”

Section: Introductionmentioning

confidence: 98%

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Structural Distortion of the Epoxy Groups in Norbornanes: A Rotational Study of exo‐2,3‐Epoxynorbornane

et al. 2015

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Exo-2,3-epoxynorbornane is studied in the gas phase by pulsed jet Fourier transform microwave spectroscopy in the 4-18 GHz region. Six isotopologues were observed and characterized in their natural abundance. The experimental substitution and effective structures were obtained. Comparison with the structure of norbornane shows significant differences in several bond lengths and valence angles upon introduction of the epoxy group. All the work is supported by quantum chemical calculations.

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Section: Theoretical Calculationsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 98%

Structural Distortion of the Epoxy Groups in Norbornanes: A Rotational Study of exo‐2,3‐Epoxynorbornane

et al. 2015

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“…Nucleobases encountered in carbonaceous chondritic meteorites include guanine, hypoxanthine, xanthine, adenine, and uracil (Martins et al, 2008;Callahan et al, 2011). Riboses have been identified in the gaseous phases of interstellar medium (Cocinero et al, 2012).…”

Section: Molecular Biomarkersmentioning

confidence: 99%

The Significance of Microbe-Mineral-Biomarker Interactions in the Detection of Life on Mars and Beyond

Röling¹,

Aerts²,

Patty³

et al. 2015

Astrobiology

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The detection of biomarkers plays a central role in our effort to establish whether there is, or was, life beyond Earth. In this review, we address the importance of considering mineralogy in relation to the selection of locations and biomarker detection methodologies with characteristics most promising for exploration. We review relevant mineral-biomarker and mineral-microbe interactions. The local mineralogy on a particular planet reflects its past and current environmental conditions and allows a habitability assessment by comparison with life under extreme conditions on Earth. The type of mineral significantly influences the potential abundances and types of biomarkers and microorganisms containing these biomarkers. The strong adsorptive power of some minerals aids in the preservation of biomarkers and may have been important in the origin of life. On the other hand, this strong adsorption as well as oxidizing properties of minerals can interfere with efficient extraction and detection of biomarkers. Differences in mechanisms of adsorption and in properties of minerals and biomarkers suggest that it will be difficult to design a single extraction procedure for a wide range of biomarkers. While on Mars samples can be used for direct detection of biomarkers such as nucleic acids, amino acids, and lipids, on other planetary bodies remote spectrometric detection of biosignatures has to be relied upon. The interpretation of spectral signatures of photosynthesis can also be affected by local mineralogy. We identify current gaps in our knowledge and indicate how they may be filled to improve the chances of detecting biomarkers on Mars and beyond.

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“…Microwave spectroscopy provides an inherently superior resolution of the molecular structure through the rotational constants, which critically depend on the mass distribution. Hence, it is an essential tool for the structural characterization of conformers, tautomers, isotopologues, and even enantiomers . In the present case, isotopic substitutions enabled the determination of the IPAS coordinates of the substituted atoms by using Kraitchman's equations .…”

Section: Resultsmentioning

confidence: 96%

Effects of Chlorination on the Tautomeric Equilibrium of 2‐Hydroxypyridine: Experiment and Theory

Calabrese

Maris

Uriarte

et al. 2016

Chemistry A European J

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What is the most significant result of this study? This work explores the intramolecular proton transfer in the tauto-meric/conformational equilibria of ab iological model system. Previous experiments and theory gave contradictory and nonconclu-sive results due to the subtle balance of inductive and mesomeric effects. In this study,t he role of halogenation at different ring positions and the influence of the solvent on the position of complex conformational and tautomeric equilibria are explored. How did each team contribute to the work? This work stems from ac ollaboration between two research groups, triggered by the Marco Polo exchange program in which Camilla Calabrese participated as aP hD student. The presented results could not be reached without the contributions of each team. The experimental part was performed with the use of two different microwave spectrometers (one at the University of Bolo-gna (Italy) and the other one at the University of the Basque Country (Spain)). The full potential of the spectral range, resolution, and sensitivity had to be exploited for the characterization of the different tautomers and conformers of the chlorine-substituted hydroxy-pyridines in the gas phase, which presents an environment free of intermolecular interactions. The results of extensive quantum chemical calculations both in the gas and in the solvent phases have been the input for the rationalization of the effects of chlori-nation at different positions of the ring. Does the research open other avenues that you would like to investigate? The results were extremely interesting and exciting, and we intend to investigate other examples of molecules that present ac omplex conformational surface, in which substitution of atoms or groups of atoms can have adrastic influence on the stability of the various structural forms. Moreover,w ew ould like to explore the influence of such substitutions on the properties related to intermolecular interactions and reactivity. Invited for the cover of this issue are the groups of EmilioJ.C ocineroa nd Sonia Melandri at the University of PaísV asco and the University of Bologna. The image depicts different possibilities that this tautomeric equilibrium can take according to the differentp ositions of the chlorinea tom, which, in manycases,are difficult to predictapriori. Read the fulltext of the article at

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Ribose Found in the Gas Phase

Cited by 38 publications

References 56 publications

Structural Distortion of the Epoxy Groups in Norbornanes: A Rotational Study of exo‐2,3‐Epoxynorbornane

Structural Distortion of the Epoxy Groups in Norbornanes: A Rotational Study of exo‐2,3‐Epoxynorbornane

The Significance of Microbe-Mineral-Biomarker Interactions in the Detection of Life on Mars and Beyond

Effects of Chlorination on the Tautomeric Equilibrium of 2‐Hydroxypyridine: Experiment and Theory

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