Ribose accelerates the repletion of the ATP pool during recovery from reversible ischemia of the rat myocardium

Zimmer, Heinz‐Gerd; Ibel, H.

doi:10.1016/s0022-2828(84)80010-3

Cited by 82 publications

(42 citation statements)

References 12 publications

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“…Pre-clinical studies have demonstrated the recovery benefits in depressed high-energy phosphates with D-ribose as well as functional improvements in the myocardium following ischemia and in isolated skeletal muscle [1][2][3][4]. Clinically, congestive heart failure patients have experienced improvements in their diastolic dysfunction, ventilatory efficiency, a better quality of life, and improved physical function activities when taking oral D-ribose [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Hematological and Biochemical parameters with extended D-Ribose ingestion

Seifert

Frelich

Shecterle³

et al. 2008

Journal of the International Society of Sports Nutrition

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D-ribose, a naturally occurring pentose carbohydrate, has been shown to replenish high-energy phosphates following myocardial ischemia and high intensity, repetitive exercise. Human studies have mainly involved short-term assessment, including potential toxicity. Reports describing adverse effects of D-ribose with prolonged ingestion have been lacking. Therefore, this study assessed the toxicity of extended consumption of D-ribose in healthy adults. Nineteen subjects ingested 20 grams/Day (10 grams, twice a Day) of ribose with serial measurements of biochemical and hematological parameters at Days 0, 7, and 14. No significant toxic changes over the 14-day assessment period occurred in complete blood count, albumin, alkaline phosphatase, gamma glutamyltransferase, alanine amiotransferase, and aspartate aminotransferase. However, D-ribose did produce an asymptomatic, mild hypoglycemia of short duration. Uric acid levels increased at Day 7, but decreased to baseline values by Day 14. D-ribose consumption for 14 days appears not to produce significant toxic changes in both hematological and biochemical parameters in healthy human volunteers.

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Section: Introductionmentioning

confidence: 99%

“…Published studies on D-ribose have mainly centered on acute, short-term investigations, ranging from hours to a few days [2,4,8,9,11,20]. This study was designed to evaluate biochemical and hematological parameters in healthy adults who consumed D-ribose for 14 days.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Hematological and Biochemical parameters with extended D-Ribose ingestion

Seifert

Frelich

Shecterle³

et al. 2008

Journal of the International Society of Sports Nutrition

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“…Since this is very small because of the limited capacity of the oxidative PPP, it takes days for a complete ATP restitution. 41,42 When there is prolonged catecholamine stimulation of the heart, cardiac function and oxygen demand are increased with a concomitant reduction in the ATP and total adenine nucleotide level.37 This tendency is counterbalanced by the simultaneous G-6-PD stimulation that leads to elevation of the PRPP pool and to an increase in adenine nucleotide biosynthesis.4 These changes are necessary for the restitution of the adenine nucleotide pool. Thus, the new synthesis of cardiac G-6-PD can be considered to be an adaptive process to keep the cardiac adenine nucleotide pool in the normal range when the heart is subjected to catecholamine stimulation.…”

Section: Resultsmentioning

confidence: 99%

Effects of norepinephrine on the oxidative pentose phosphate pathway in the rat heart.

Zimmer¹,

Lankat–Buttgereit²,

Kolbeck-Rühmkorff³

et al. 1992

Circulation Research

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To examine whether stimulation of c-adrenergic receptors may affect the oxidative pentose phosphate pathway (PPP) in the rat heart, norepinephrine (NE) and the c-adrenergic agonist norfenephrine were used. NE was administered as a continuous intravenous infusion in awake rats for 3 days. It stimulated the activity of cardiac glucose-6-phosphate dehydrogenase (G-6-PD), the first and regulating enzyme of the oxidative PPP, in a dose-dependent manner. With the highest dose (0.2 mg * kg`* hr-'), there was also a time-dependent enhancement. The increase observed after 48 hours was attenuated partially by the (3-receptor blocker metoprolol and the a!-receptor blocker prazosin. It was entirely abolished when both drugs were administered. Carvedilol, a j3-adrenergic blocker and vasodilator with eel-blocking activity (0.5 mg * kg`* hr-1), prevented the NE-induced increase in cardiac G-6-PD activity, in functional parameters (heart rate, left ventricular systolic pressure, and left ventricular dP/dtmax), and in the heart weight/body weight ratio. The ae-adrenergic stimulator norfenephrine increased myocardial G-6-PD activity; prazosin prevented this stimulation. NE and norfenephrine also elevated the available pool of cardiac 5-phosphoribosyl-1-pyrophosphate. G-6-PD activity was enhanced in cardiac myocytes freshly isolated from the left ventricle of rats that had received NE infusion for 3 days (12.3±1.4 units/g protein) compared with control rats (1.5±0.4 units/g protein). The activity of 6-phosphogluconate dehydrogenase, one of the enzymes in the oxidative PPP, was elevated only moderately from 12.7±0.7 to 19.1± 1.4 units/g protein. Combined aand f3-receptor blockade with carvedilol attenuated these effects. Using Northern blot analysis, we showed that G-6-PD mRNA was elevated in a time-dependent manner in hearts of NE-treated rats, reaching a 2.6-fold increase after 3 days. This increase was abolished with carvedilol. The 6-phosphogluconate dehydrogenase mRNA was only slightly and unspecifically enhanced. These results indicate that both crand j3-adrenergic receptors contribute to the stimulation of the oxidative PPP by predominant elevation of G-6-PD mRNA. (Circulation Research 1992;71:451-459) KEY WoRDs * adenine nucleotide metabolism * carvedilol * molecular biology * catecholamines * glucose-6-phosphate dehydrogenase * 6-phosphogluconate dehydrogenase * rat heart function C atecholamines have multiple effects on the function, metabolism, and morphology of the heart. Specifically, stimulation of 83-adrenergic receptors is known to induce a positive chronotropic and inotropic effect, to increase via cAMP glycogenolysis and lipolysis,1 to shift the isomyosin from V3 to the V1 form,2 and to induce cardiac hypertrophy.3 Recently, a new metabolic effect has been found in that f3-adrenergic stimulation increased the activity of cardiac glucose-6-phosphate dehydrogenase (G-6-PD), the first and rate-limiting enzyme of the oxidative pentose phosphate pathway (PPP).4 This pathway is the link between carbohydrate and fatt...

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“…245 In the heart, the PPP is activated during hypertrophy [132][133][134] and heart failure, 135 and modulating the activity of this pathway regulates the severity of cardiac pathology. [136][137][138][139][140][141] Similarly, O-linked β-N-acetylglucosamine (OGlcNAc)-modified proteins, which require synthesis of the sugar donor UDPGlcNAc via the HBP, 147,246 are elevated in hypertrophied and failing hearts. 223, 247-of this pathway may underlie pathologic cardiac hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

“…In the heart, the PPP is activated during pathological hypertrophy [132][133][134] and heart failure, 135 and modulating pathway activity regulates the severity of cardiac pathology. [136][137][138][139][140][141] Similarly, growth of a cell cannot occur without expansion of the cellular membrane which requires increased bioavailability of phospholipids derived from the GLP. Although less is known about the GLP, increased pathway activity may in fact contribute to pathologic cardiac hypertrophy.…”

Section: Metabolism As a Contributing Factor To Growthmentioning

confidence: 99%

Metabolic regulation of myocardial adaptation to exercise.

Gibb¹

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Ribose accelerates the repletion of the ATP pool during recovery from reversible ischemia of the rat myocardium

Cited by 82 publications

References 12 publications

Assessment of Hematological and Biochemical parameters with extended D-Ribose ingestion

Assessment of Hematological and Biochemical parameters with extended D-Ribose ingestion

Effects of norepinephrine on the oxidative pentose phosphate pathway in the rat heart.

Metabolic regulation of myocardial adaptation to exercise.

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