Ribonucleotide reductase: An intracellular target for the male antifertility agent, gossypol

McClarty, Grant; Chan, Arthur K.; Creasey, David C.; Wright, Jim A.

doi:10.1016/0006-291x(85)91875-3

Cited by 11 publications

(1 citation statement)

References 20 publications

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“…Yu et al (2001) attribute its antifertility action to inhibition of mitochondrial LDH-C 4 (LDH-X), which is present only in the testes and sperm and is essential for energy production. However, the mode of action is complex and involves the inhibition of a number of essential enzyme systems, including ribonucleotide reductase (McClarty et al, 1985), malate dehydrogenase (MDH), glyceraldehyde-3-phosphate dehydrogenase (GA 3 PDH) (Ikeda, 1990), and cytoplasmic phospholipase A 2 (cPLA 2 ). The latter enzyme plays an important role in the acrosomal reaction during sperm maturation (Dodou, 2005;Vainio et al, 1985).…”

Section: Antifertility/contraceptivementioning

confidence: 99%

Therapeutic potential of gossypol: An overview

Neghab

Goliaei

2013

Pharmaceutical Biology

100

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Context: Polyphenols are naturally occurring compounds found in fruits, vegetables, cereals, and beverages. Polyphenols occupy a unique place in biological science for their pharmacological properties. Gossypol is a polyphenolic compound that has attracted attention because of its biological effects. Objective: Gossypol is reported to exhibit antifertility, antioxidant, anticancer, antivirus, antiparasitic, and antimicrobial properties and lower plasma cholesterol. These are summarized with attention to the mechanisms of activity. Methods: This review summarizes the results of studies obtained in a comprehensive search of ScienceDirect, PubMed, Scirus, and Web of Science. Results and conclusion: The results of these studies provide a comprehensive understanding of the biological action of gossypol and its potential for the prevention of and therapy for resistant tumors and chronic human diseases such as HIV, malaria, and psoriasis.

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Section: Antifertility/contraceptivementioning

confidence: 99%

Therapeutic potential of gossypol: An overview

Neghab

Goliaei

2013

Pharmaceutical Biology

100

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Genotoxic effects of gossypol acetic acid on cultured murine erythroleukemia cells

Majumdar

Daly

Kleemeyer

et al. 1991

Environ and Mol Mutagen

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Gossypol acetic acid, a male anti-fertility drug, was evaluated for its effects on cell multiplication, chromosomes, scheduled and unscheduled DNA synthesis, and the surface ultrastructure in cultured murine erythroleukemia cells (clone 6A11A). Gossypol treatments inhibited cell multiplication at 10 and 20 micrograms/ml concentrations and this inhibitory effect increased with elevated dosage and prolonged treatment. Gossypol significantly depressed the mitotic index but did not alter chromosome numbers or increase the frequency of chromosomal structural abnormalities. Cell fraction techniques revealed that gossypol induced a negative effect on cellular DNA synthesis at concentrations as low as 3.3 micrograms/ml after 24 hr of treatment. The number of cells undergoing DNA synthesis decreased with increasing dosages and durations of drug exposure. An unscheduled DNA synthesis assay (UDS) found gossypol to be an active UDS-inducing agent at certain dose levels and treatment times, as measured by increase in net nuclear gain and percentage of UDS cells (ANOVA, Bonferroni test, P less than 0.05). A scanning electron microscope study revealed that 10 micrograms/ml treatment with gossypol caused changes in mouse erythroleukemia cell surface ultrastructure characterized by general balding and the appearance of holes, often after 48 hr of treatment.

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Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: I. The activity for DNA synthesis

Zhang

Yan

et al. 1989

Contraception

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Ribonucleotide reductase: An intracellular target for the male antifertility agent, gossypol

Cited by 11 publications

References 20 publications

Therapeutic potential of gossypol: An overview

Therapeutic potential of gossypol: An overview

Genotoxic effects of gossypol acetic acid on cultured murine erythroleukemia cells

Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: I. The activity for DNA synthesis

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