Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth
Laura R Diaz,
Jon Gil-Ranedo,
Karolina J Jaworek
et al.
Abstract:Cell commitment to tumourigenesis and the onset of uncontrolled growth are critical determinants in cancer development but the early events directing tumour initiating cell (TIC) fate remain unclear. We reveal a single-cell transcriptome profile of brain TICs transitioning into tumour growth using the brain tumour (brat) neural stem cell-based Drosophila model. Prominent changes in metabolic and proteostasis-associated processes including ribogenesis are identified. Increased ribogenesis is a known cell adapta… Show more
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