Riboflavin (vitamin B2) and oxidative stress: a review

Ashoori, Marziyeh; Saedisomeolia, Ahmad

doi:10.1017/s0007114514000178

Cited by 276 publications

(243 citation statements)

References 53 publications

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“…Furthermore, we observed that ectopic expression of GPR172B inhibited senescence. This effect appears to be reasonable because GPR172B is a membrane transporter for riboflavin (also known as vitamin B2) that acts as a coenzyme for redox enzymes essential for cellular homeostasis4546. This result raises the possibility that p53 also drives a negative feedback loop that limits activation of senescence-inducing signalling pathways to prevent accidental induction of senescence.…”

Section: Discussionmentioning

confidence: 99%

Identification of cellular senescence-specific genes by comparative transcriptomics

Nagano

Nakano

Nakashima

et al. 2016

Sci Rep

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Cellular senescence is defined as permanent cell cycle arrest induced by various stresses. Although the p53 transcriptional activity is essential for senescence induction, the downstream genes that are crucial for senescence remain unsolved. Here, by using a developed experimental system in which cellular senescence or apoptosis is induced preferentially by altering concentration of etoposide, a DNA-damaging drug, we compared gene expression profiles of senescent and apoptotic cells by microarray analysis. Subtraction of the expression profile of apoptotic cells identified 20 genes upregulated specifically in senescent cells. Furthermore, 6 out of 20 genes showed p53-dependent upregulation by comparing gene expression between p53-proficient and -deficient cells. These 6 genes were also upregulated during replicative senescence of normal human diploid fibroblasts, suggesting that upregulation of these genes is a general phenomenon in senescence. Among these genes, 2 genes (PRODH and DAO) were found to be directly regulated by p53, and ectopic expression of 4 genes (PRODH, DAO, EPN3, and GPR172B) affected senescence phenotypes induced by etoposide treatment. Collectively, our results identified several proteins as novel downstream effectors of p53-mediated senescence and provided new clues for further research on the complex signalling networks underlying the induction and maintenance of senescence.

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Section: Discussionmentioning

confidence: 99%

Identification of cellular senescence-specific genes by comparative transcriptomics

Nagano

Nakano

Nakashima

et al. 2016

Sci Rep

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“…Ashoori and Saedisomeolia [27] explained in their study "Riboflavin (vitamin B2) and oxidative stress: A review" the confirmation of antioxidant nature of riboflavin and indicated that this vitamin can protect the body against oxidative stress, especially lipid peroxidation and reperfusion oxidative injury. The mechanisms by which riboflavin protects the body against oxidative stress may be attributed to the glutathione redox cycle and also to other possible mechanisms such as the conversion of reduced riboflavin to the oxidised form.…”

Section: Vitamin B 2 (Riboflavin)mentioning

confidence: 99%

Free Radical Scavenging Activity and Antioxidants of Hydrocotyle vulgaris L. (Pennywort): Baseline Study in Developing Biocosmetic-Antidote for Pathological Aging

Ureta¹,

Mejico²,

Maranan³

2018

IJPPE

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Abstract. Pathological aging due to harmful free radicals and oxidative stress has been a serious threat to human health. Thus, the study aimed to evaluate the free radical scavenging activity, antioxidants, essential vitamins, and physicochemical properties of Hydrocotyle vulgaris L. (Pennywort) which could serve as basis in developing a biocosmetic antidote for pathological aging. H. vulgaris L. plant was harvested, air dried and then extracted via soxhlet. UV-vis spectroscopy was used for scavenging activity and antioxidants of the plant while High Performance Liquid Chromatography (HPLC) was applied for the identification of essential vitamins. Phytochemicals, pH and spreadability values of the plant were also tested. Results revealed that H. vulgaris L. has an abundant presence of flavonoid and alkaloid while traced presence of tannin. Good trend for scavenging activity was also observed exhibiting low absorbance of possible free radicals with IC 50 of 29.75 and antioxidant activity of 158.13 (Total Phenolics as gallic acid in %w/w). Meanwhile, β-carotene (10.4 mg/kg), Riboflavin (4.08mg/kg), and Vitamins C (70.2mg/kg) and E (26.9mg/kg) were also found in the plant. Non-irritating pH levels of 5.7 and 7.14 for 50% and 75% concentrations of the extracts with good spreadability value of 17.51 g•cm/sec (for 75% concentration) were also obtained. Based on the findings of the study, Pennywort has a very promising therapeutic characteristics with its good scavenging activity and antioxidants. Thus, the development of a biocosmetic product that could serve as an antidote for pathological aging from Pennywort appeared to be very apparent.

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“…It has been reported in clinical studies that riboflavin may reduce the pain in humans [21,22], although recent papers did not support the prophylactic effects of riboflavin [23,24]. More recent studies have suggested that at least some subtypes of migraines may be related to a mitochondria defect.…”

Section: Introductionmentioning

confidence: 99%

“…More recent studies have suggested that at least some subtypes of migraines may be related to a mitochondria defect. Different types of evidence support a relationship between mitochondria and migraines [21,22]. Riboflavin works as a coenzyme in the mitochondrial electron transport chain [21].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Riboflavin and Selenium on Brain Microsomal Ca2+-ATPase and Oxidative Damage Caused by Glyceryl Trinitrate in a Rat Headache Model

Nazıroğlu

Çelik

Uğuz

et al. 2014

Biol Trace Elem Res

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Migraine headaches are considered to be associated with increased mitochondrial energy metabolism. Mitochondrial oxidative stress is also important in migraine headache pathophysiology although riboflavin and selenium (Se) induced a modulator role on mitochondrial oxidative stress in the brain. The current study aimed to determine the effects of Se with/without riboflavin on the microsomal membrane Ca(2+)-ATPase (MMCA), lipid peroxidation, antioxidant, and electroencephalography (EEG) values in glyceryl trinitrate (GTN)-induced brain injury rats. Thirty-two rats were randomly divided into four groups. The first group was used as the control, and the second group was the GTN group. Se and Se plus oral riboflavin were administered to rats constituting the third and fourth groups for 10 days prior to GTN administration. The second, third, and fourth groups received GTN to induce headache. Ten hours after the administration of GTN, the EEG records and brain cortex samples were obtained for all groups. Brain cortex microsomes were obtained from the brain samples. The brain and microsomal lipid peroxidation levels were higher in the GTN group compared to the control group, whereas they were decreased by selenium and selenium + riboflavin treatments. Vitamin A, vitamin C, vitamin E, and reduced glutathione (GSH) concentrations of the brain and MMCA, GSH and glutathione peroxidase values of microsomes were decreased by the GTN administration, although the values and β-carotene concentrations were increased by Se and Se + riboflavin treatments. There was no significant change in EEG records of the four groups. In conclusion, Se with/without riboflavin administration protected against GTN-induced brain oxidative toxicity by inhibiting free radicals and the modulation of MMCA activity and supporting the antioxidant redox system.

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Riboflavin (vitamin B₂) and oxidative stress: a review

Cited by 276 publications

References 53 publications

Identification of cellular senescence-specific genes by comparative transcriptomics

Identification of cellular senescence-specific genes by comparative transcriptomics

Free Radical Scavenging Activity and Antioxidants of <i>Hydrocotyle vulgaris </i>L<i>.</i> (Pennywort): Baseline Study in Developing Biocosmetic-Antidote for Pathological Aging

Protective Effects of Riboflavin and Selenium on Brain Microsomal Ca2+-ATPase and Oxidative Damage Caused by Glyceryl Trinitrate in a Rat Headache Model

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