Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats

Peraza, Armando Valenzuela; Guzmán, David Calderón; Brizuela, Norma Osnaya; Herrera, Maribel Ortíz; Olguı́n, Hugo Juárez; Silva, Miroslava Lindoro; Tapia, Belen Juarez; Mejía, Gerardo Barragán

doi:10.1186/s12868-018-0474-4

Cited by 20 publications

(20 citation statements)

References 24 publications

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“…In some experimental studies, the protective effects of riboflavin on ROS have also been reported (32,33,35,45) . In these studies, the beneficial effect of riboflavin supplementation (32,33,45) and the deleterious effect of its deficiency (33,35) on ROS levels in different tissues have been indicated. An in vitro study also has shown that riboflavin depletion in intestinal cells could lead to overproduction of ROS in these cells (46) .…”

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confidence: 89%

Riboflavin is an antioxidant: a review update

2022

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Aerobic organisms need antioxidant defense systems to deal with free radicals which either are produced during aerobic respiration or may have an external origin. Oxidative stress, which is resulted from an imbalance between the production of free radicals and the ability of antioxidant defense mechanism to deactivate them, is involved in the development of many chronic diseases such as cancer, diabetes, cardiovascular diseases, and some neurodegenerative diseases. Reinforcing the antioxidant potential of the body has been considered as a strategy which could prevent and manage such conditions. In the previous review article published by British Journal of Nutrition, in 2014, for the first time, we concluded that riboflavin could alleviate oxidative stress. Although riboflavin can serve as a prooxidant when exposed to ultraviolet irradiation, the literature is replete with studies that support its antioxidant properties. Furthermore, recent evidence suggest that riboflavin may have a therapeutic potential in many conditions in which oxidative stress is involved, although, the therapeutic efficacy of riboflavin as an antioxidant requires further study under conditions of wellness and clinical disease.

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confidence: 89%

Riboflavin is an antioxidant: a review update

2022

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“…Riboflavin seems to also reduce the oxidative damage after reperfusion, through a direct action on free radicals, as shown by studies on rabbits’ hearts after infarction [162], mice ischemic liver cells [163], and rats’ brains [164]. In these cases, vitamin B2 reduces edema and neuronal death after traumatic brain injury [151,160,164,165]. Riboflavin, together with folate, lowers homocysteine levels, hence helping to avoid vascular and toxic damages: FAD is needed in the one-carbon metabolism cycle to reduce 5,10-methylenetetrahydrofolate (5,10-MTHF) to 5-methyl THF which, in turn, provides the methyl group for homocysteine re-methylation to methionine [158,161,166].…”

Section: Vitamin B2 (Riboflavin)mentioning

confidence: 99%

B Vitamins and Fatty Acids: What Do They Share with Small Vessel Disease-Related Dementia?

Moretti

Peinkhofer

2019

IJMS

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Many studies have been written on vitamin supplementation, fatty acid, and dementia, but results are still under debate, and no definite conclusion has yet been drawn. Nevertheless, a significant amount of lab evidence confirms that vitamins of the B group are tightly related to gene control for endothelium protection, act as antioxidants, play a co-enzymatic role in the most critical biochemical reactions inside the brain, and cooperate with many other elements, such as choline, for the synthesis of polyunsaturated phosphatidylcholine, through S-adenosyl-methionine (SAM) methyl donation. B-vitamins have anti-inflammatory properties and act in protective roles against neurodegenerative mechanisms, for example, through modulation of the glutamate currents and a reduction of the calcium currents. In addition, they also have extraordinary antioxidant properties. However, laboratory data are far from clinical practice. Many studies have tried to apply these results in everyday clinical activity, but results have been discouraging and far from a possible resolution of the associated mysteries, like those represented by Alzheimer’s disease (AD) or small vessel disease dementia. Above all, two significant problems emerge from the research: No consensus exists on general diagnostic criteria—MCI or AD? Which diagnostic criteria should be applied for small vessel disease-related dementia? In addition, no general schema exists for determining a possible correct time of implementation to have effective results. Here we present an up-to-date review of the literature on such topics, shedding some light on the possible interaction of vitamins and phosphatidylcholine, and their role in brain metabolism and catabolism. Further studies should take into account all of these questions, with well-designed and world-homogeneous trials.

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“…Plasma membrane phospholipids in neurons are in close contact with structural proteins embedded in the lipid bilayer, from which Na + ,K + -ATPase is responsible for keeping the ionic interchange through this bilayer by stimulating Na + and K + flows. Inhibition of Na + ,K + -ATPase activity alters the ionic interchange within the CNS (9).…”

Section: Laboratory Of Neurosciences Instituto Nacional De Pediatría mentioning

confidence: 99%

Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats

et al. 2019

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The aim of the present study was to determine the effect of sildenafil on dopamine, 5-hydroxyindol acetic acid (5-HIAA) and selected biomarkers of oxidative stress in the brain of hypoglycemic rats. The animals were treated intraperitoneally as follows: group 1 (control), saline solution; group 2, insulin (10 U per rat or 50 U kg−1); group 3, insulin + single dose of sildenafil (50 U kg−1 + 50 mg kg–1); group 4, insulin + three doses of sildenafil every 24 hours (50 U kg−1 + 50 mg kg−1). In groups 2, 3 and 4, insulin was administered every 24 hours for 10 days. Blood glucose was measured after the last treatment. On the last day of the treatment, the animals´ brains were extracted to measure the levels of oxidative stress markers [H2O2, Ca2+,Mg2+-ATPase, glutathione and lipid peroxidation (TBARS)], dopamine and 5-HIAA in the cortex, striatum and cerebellum/medulla oblongata by validated methods. The results suggest that administration of insulin in combination with sildenafil induces hypoglycemia and hypotension, enhances oxidative damage and provokes changes in the brain metabolism of biogenic amines. Administration of insulin and sildenafil promotes biometabolic responses in glucose control, namely, it induces hypoglycemia and hypotension. It also enhances oxidative damage and provokes changes in the brain metabolism of biogenic amines.

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Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats

Cited by 20 publications

References 24 publications

Riboflavin is an antioxidant: a review update

Riboflavin is an antioxidant: a review update

B Vitamins and Fatty Acids: What Do They Share with Small Vessel Disease-Related Dementia?

Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats

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