Riboflavin and migraine: the bridge over troubled mitochondria

Colombo, Bruno; Saraceno, Lorenzo; Comı, Gıancarlo

doi:10.1007/s10072-014-1755-z

Cited by 52 publications

(42 citation statements)

References 21 publications

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“…RCT studies in adults has confirmed that riboflavin is safe and probably effective in migraine prophylaxis, based on level B evidence. The bridge is troubled mitochondria, Riboflavin, a major co-factor in oxidative metabolism, may overcome this impairment (Colombo et al, 2014). Riboflavin may be a preventative medication for paediatric migraine (O'Brien and Hershey, 2010).…”

Section: Introductionmentioning

confidence: 99%

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Liu¹,

Yu²,

Zhu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 16 (3), 909-913 IntroductionIn 2013, colorectal cancer was newly diagnosed in 73,680 males in the United States; 26,300 died of the disease. It was newly diagnosed in 69,140 females and 24,530 died (Siegel et al., 2013). Indeed, colorectal cancer is the third most commonly diagnosed cancer in males and the second in females, with more than 1.2 million new cases and 608,700 deaths estimated to have occurred in 2008 (Center et al., 2009.Vitamin B2 (chemical formula: C17H20N4O6) also known as riboflavin . In fact, the flavin in riboflavin comes from flavus, the Latin word for yellow. (yellow enzymes play a role of hydrogen in the biological oxidation reduction). Vitamin B2 is one of many nutrients required to recycle glutathione, which is one of the most important antioxidants in the human body. (From a chemical standpoint, what B2 does is facilitate the conversion of oxidized glutathione into reduced glutathione.) (Yasuda and Hiraoka, 1999).Riboflavin is unique among the water-soluble vitamins in that milk and dairy products make the greatest contribution to its intake in Western diets. Meat and fish are also good sources of riboflavin, and certain fruit and vegetables, especially dark-green vegetables, contain reasonably high concentrations (Powers, 2003). Vitamin B2 has limited storage , So it need a food supplement Conclusions: This is the first meta-analysis to study links between vitamin B2 and colorectal cancer. We found vitamin B2 intake was inversely associated with risk of colorectal cancer. However, further research and large sample studies need to be conducted to better validate the result.

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Section: Introductionmentioning

confidence: 99%

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Liu¹,

Yu²,

Zhu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…More recently, in a 31 P‐MRS study at 3 tesla, Reyngoudt et al documented a decrease in phosphocreatine and adenosine triphosphate concentrations in a sample of migraine without aura patients compared to control subjects, thus supporting the hypothesis of mitochondrial dysfunctions in migraine subjects. Furthermore, the literature data suggest the possible efficacy in migraine preventive treatment of riboflavin, a precursor of flavin mononucleotide and flavin adenine dinucleotide, playing a key role in the mitochondrial electron transport chain, and Coenzyme Q10, a small hydrophobic substance acting as an electron carrier in the mitochondrial respiratory chain …”

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confidence: 99%

Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication‐Overuse Headache

et al. 2015

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The data from the present study suggest that antioxidant capacity is lower in chronic migraine patients and medication-overuse headache compared to healthy headache-free subjects, with no differences between patients with triptan or nonsteroidal anti-inflammatory drug overuse. Further investigation is certainly necessary in order to define the causal or consequential role of an imbalance between pro-oxidants and antioxidant defenses in migraine pathogenesis and "chronification" and the possible therapeutic implications in clinical practice.

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“…The hypothesis of the mitochondrial component in migraine neurobiology has been supported in several studies, 32, 33, 34, 35, 36, 37 suggesting that an impairment of the mitochondrial oxidative metabolism, which ultimately causes energy failure in neurons and astrocytes, triggers migraine mechanisms. Furthermore, different types of assays performed in migraine sufferers have shown a decreased activity of the respiratory chain enzymes 33 and a correlation between the extent of the energy disturbance (low ATP levels), and the clinical phenotype severity.…”

Section: Discussionmentioning

confidence: 91%

A splice variant in the ACSL5 gene relates migraine with fatty acid activation in mitochondria

et al. 2016

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Genome-wide association studies (GWAS) in migraine are providing the molecular basis of this heterogeneous disease, but the understanding of its aetiology is still incomplete. Although some biomarkers have currently been accepted for migraine, large amount of studies for identifying new ones is needed. The migraine-associated variant rs12355831:A>G (P=2 × 10−6), described in a GWAS of the International Headache Genetic Consortium, is localized in a non-coding sequence with unknown function. We sought to identify the causal variant and the genetic mechanism involved in the migraine risk. To this end, we integrated data of RNA sequences from the Genetic European Variation in Health and Disease (GEUVADIS) and genotypes from 1000 GENOMES of 344 lymphoblastoid cell lines (LCLs), to determine the expression quantitative trait loci (eQTLs) in the region. We found that the migraine-associated variant belongs to a linkage disequilibrium block associated with the expression of an acyl-coenzyme A synthetase 5 (ACSL5) transcript lacking exon 20 (ACSL5-Δ20). We showed by exon-skipping assay a direct causality of rs2256368-G in the exon 20 skipping of approximately 20 to 40% of ACSL5 RNA molecules. In conclusion, we identified the functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping, as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Δ20 molecules, a mitochondrial located enzyme, is involved in migraine pathology.

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Riboflavin and migraine: the bridge over troubled mitochondria

Cited by 52 publications

References 21 publications

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication‐Overuse Headache

A splice variant in the ACSL5 gene relates migraine with fatty acid activation in mitochondria

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