Ribociclib (RIB) plus letrozole (LET) in male patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor-2–negative (HER2–) advanced breast cancer (ABC) from the CompLEEment-1 trial

Campone, M.; Laurentiis, Michelino De; Zamagni, Claudio; Kudryavcev, Igor; Agterof, Mariette J; Brown-Glaberman, Ursa; Palácová, Markéta; Chatterjee, Sharmistha; Menon-Singh, Lakshmi; Wu, Jiwen; Zhou, Katie; Martin, M.

doi:10.1093/annonc/mdz242.023

Cited by 2 publications

(3 citation statements)

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“…On the other hand, HER2-positive cancers grow and spread faster than other types of cancers. Therefore, the introduction of HER2-guided therapies can have a positive effect on the treatment of patients with breast and stomach/stomach cancer with HER2 ( Scaltriti et al, 2007 ; Campone et al, 2019 ). There are currently several laboratory techniques used for the detection of HER2.…”

Section: Introductionmentioning

confidence: 99%

A Sandwich-Type Electrochemical Immunosensor Using Antibody-Conjugated Pt-Doped CdTe QDs as Enzyme-Free Labels for Sensitive HER2 Detection Based on a Magnetic Framework

Ehzari

Safari

2022

Front. Chem.

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Tumor markers are highly sensitive and play an important role in the early diagnosis of cancer. We developed an electrochemical sandwich-type immunosensor that detects human epidermal growth factor receptor 2 (HER2). Magnetic framework (Fe3O4@ TMU-24) and AuNPs (Fe3O4@ TMU-24 -AuNPs) are utilized in this sensing platform. In addition to their high specific surface area and excellent biocompatibility, Fe3O4@ TMU-24-AuNPs nanocomposites exhibited excellent electrocatalytic properties. The primary antibody of HER2 (Ab1) was immobilized on the surface of the Fe3O4@ TMU-24-AuNPs. In this sensing method, palatine doped to CdTe QDs (Pt: CdTe QDs) is utilized as a novel labeling signal biomolecule (secondary antibodies). Pt: CdTe QDs own good biocompatibility and excellent catalytic performance. The amperometric technique was used to achieve the quantitative determination of HER2 by using a sandwich-type electrochemical immunosensor. Under the optimum conditions, the dependency of the current signal and HER2 concentration showed a linear region from 1 pg ml−1–100 ng ml−1 with 0.175 pg ml−1 as the limit of detection. This biosensing device also showed long stability and good reproducibility, which can be used for the quantitative assay of HER2.

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Section: Introductionmentioning

confidence: 99%

A Sandwich-Type Electrochemical Immunosensor Using Antibody-Conjugated Pt-Doped CdTe QDs as Enzyme-Free Labels for Sensitive HER2 Detection Based on a Magnetic Framework

Ehzari

Safari

2022

Front. Chem.

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“…34 It is demonstrated that raised serum HER2 levels are related to metastatic breast cancer and adverse reactions to chemotherapy and hormonotherapy. 35 Thus, the early detection of HER2 is of great significance for the early diagnosis and treatment of cancer. 36 Conducting polymers, due to their outstanding electronic conductivity, low-cost fabrication, and high stability, have been recognized to be ideal materials as substrates for electrochemical biosensors.…”

mentioning

confidence: 99%

“…HER2 overexpression has been proved to be associated with the progression of 20–30% of breast cancer tumors . It is demonstrated that raised serum HER2 levels are related to metastatic breast cancer and adverse reactions to chemotherapy and hormonotherapy . Thus, the early detection of HER2 is of great significance for the early diagnosis and treatment of cancer .…”

mentioning

confidence: 99%

Antifouling Peptide Hydrogel Based Electrochemical Biosensors for Highly Sensitive Detection of Cancer Biomarker HER2 in Human Serum

et al. 2021

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A facile strategy for the electrochemical detection of human epidermal growth factor receptor 2 (HER2), a breast cancer biomarker, was presented via the fabrication of an antifouling sensing interface based on the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and a biocompatible peptide hydrogel. The peptide hydrogel prepared from a designed short peptide of Phe-Glu-Lys-Phe functionalized with a fluorene methoxycarbonyl group (Fmoc-FEKF) enabled excellent activity preservation for the immobilized biomolecules, and its good hydrophilicity facilitated effective alleviation of nonspecific adsorption or biofouling, while the PEDOT film provided a highly stable and conducting substrate. The developed biosensor was highly sensitive and selective for HER2 detection, with a wide linear response range from 0.1 ng mL–1 to 1.0 μg mL–1 and a low limit of detection of 45 pg mL–1. Moreover, the peptide hydrogel based biosensor was feasible to use for complex biological samples, and it was capable of detecting HER2 in human serum with clinically acceptable accuracy, manifesting a promising potential for practical application.

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Ribociclib (RIB) plus letrozole (LET) in male patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor-2–negative (HER2–) advanced breast cancer (ABC) from the CompLEEment-1 trial

Cited by 2 publications

References 0 publications

A Sandwich-Type Electrochemical Immunosensor Using Antibody-Conjugated Pt-Doped CdTe QDs as Enzyme-Free Labels for Sensitive HER2 Detection Based on a Magnetic Framework

A Sandwich-Type Electrochemical Immunosensor Using Antibody-Conjugated Pt-Doped CdTe QDs as Enzyme-Free Labels for Sensitive HER2 Detection Based on a Magnetic Framework

Antifouling Peptide Hydrogel Based Electrochemical Biosensors for Highly Sensitive Detection of Cancer Biomarker HER2 in Human Serum

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