Ribes orientale: A novel therapeutic approach targeting rheumatoid arthritis with reference to pro-inflammatory cytokines, inflammatory enzymes and anti-inflammatory cytokines

Uttra, Ambreen Malik; Alamgeer, -; Shahzad, Muhammad; Shabbir, Arham; Saleem, Sidrah; Bukhari, Ishfaq A.; Assiri, Asaad

doi:10.1016/j.jep.2019.03.019

Cited by 46 publications

(36 citation statements)

References 30 publications

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“…Our outcomes on hematological variables in the CFA-induced arthritic model are synchronous with a prior study of Jalalpure et al 45 It indicated that adjuvant-induced hematological parameters like elevation in the WBC count and ESR and reduction in RBC and HB were also considerably changed by M. ferrea administration at 300 mg/kg and 500 mg/kg oral dose, supporting our current results. 45 The current results are in accordance with those of Uttra et al, 34 where a decrease in Hb and RBCs and an increase in platelets were observed, and ESR and WBCS counts were reported in CFA-injected arthritic animals. Furthermore, increased ALP, ALT, AST, RF, and CRP levels were noted in disease control animals, while treatment with R. orientale extract, its aqueous and n -butanol fractions, and piroxicam decreased these levels in serum.…”

Section: Discussionsupporting

confidence: 93%

“…Accordingly, it could be accepted due to these outcomes; protection against protein denaturation and auto antigen production of A. bettzickiana may probably be responsible for its antiarthritic potential. 34 In the current study, our findings of protein denaturation assays using fresh hen albumin and bovine serum albumin were in agreement with previously documented research work in which plant extracts and standard exhibited a dose-dependent inhibition of protein denaturation. 34 , 35 …”

Section: Discussionsupporting

confidence: 92%

“… 37 A. bettzickiana extract significantly reduced the arthritic index and protected against morphological alterations of rheumatoid arthritis by reducing swelling and redness, along with inhibiting the growth of secondary lesions because of its antiarthritic potential. 34 Our findings of arthritic scoring in the CFA-induced arthritic study are synchronous with a previous study of Uttra et al 34 They reported that CFA injection showed arthritic lesions in arthritic rats in contrast to vehicle control rats, while administration of Ribes orientale reduced these arthritic signs. On the 28th day of treatment, all animals administered with R. orientale extract, fractions, and piroxicam significantly reduced the arthritic score.…”

Section: Discussionsupporting

confidence: 90%

“…They observed that the highest decrease in arthritic score was achieved with aqueous ethanolic extract. 34 …”

Section: Discussionmentioning

confidence: 99%

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Antiarthritic Potential of Comprehensively Standardized Extract of Alternanthera bettzickiana: In Vitro and In Vivo Studies

et al. 2020

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Alternanthera bettzickiana is being used as a folk remedy for treating arthritis by conventional healers in Thailand. The current research was undertaken to explore the antiarthritic potential of A. bettzickiana ethanolic extract (ABEE). Plant characterization, molecular docking, and in vitro and in vivo (ABEE at 250, 500, and 1000 mg/kg was administered orally to rats once daily for 28 days) studies to explore the antiarthritic effect and enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (RT-PCR) analyses were performed. Oxidative stress biomarkers (superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA)) in the serum and histopathological and radiographic assessment of joints were also carried out. Gallic acid, catechin, chlorogenic acid, sinapic acid, quercetin, and γ- and α-tocopherol were identified in high-performance liquid chromatography (HPLC). Molecular docking revealed a strong interaction between these compounds and cyclooxygenase (COX) enzymes. The extract significantly subdued paw swelling and arthritic scoring, inhibited cachexia, and considerably improved biochemical and hematological modifications. SOD and CAT levels increased and the MDA level decreased in ABEE-treated rats dose-dependently. Radiographic and histopathological analyses also supported the antiarthritic effect of ABEE, which was linked with the downregulation of nuclear factor (NF)-kB, COX-2, interleukin (IL)-6, tumour necrosis factor (TNF)-α, and IL-1β and upregulation of IL-10, I-kB, and IL-4 as compared to disease control rats. Results suggested that A. bettzickiana possessed antiarthritic potential, supporting its folkloric use for treating rheumatoid arthritis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

“…They observed that the highest decrease in arthritic score was achieved with aqueous ethanolic extract. 34 …”

Section: Discussionmentioning

confidence: 99%

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Antiarthritic Potential of Comprehensively Standardized Extract of Alternanthera bettzickiana: In Vitro and In Vivo Studies

et al. 2020

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“…[ 99 ] In research, the active phytoconstituent phytosterol beta‐sitosterol presented to be inhibiting the transcriptional factor NF‐κB and its involvement in regulating genes for elevated inflammatory mediator levels tends to be implicated in the rheumatoid arthritis. [ 100 ] Furthermore, the preclinical animal study that used the aqueous methanolic extract such as ethyl acetate, n‐butanol and aqueous form of various parts of plant roots and stem showed the anti‐arthritic activity in CFA‐induced arthritic models and inhibited the production of inflammatory mediators, that is IFN‐α, PDGF and cytokines (IL‐1, IL 6 and TNF‐α). [ 101 ] Therefore, it has been concluded that B. orthobotrys has been potential therapeutic agent for the treatment of RA due to the significant improvement in synovial hyperplasia and inflammatory infiltration.…”

Section: The Various Herbal Plants Used In the Treatment Of Rheumatoimentioning

confidence: 99%

Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis

Singh

Mahajan

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Rheumatoid arthritis is a chronic autoimmune disease manifested clinically by polyarthralgia associated with joint dysfunction triggering the antibodies targeting against the self‐neoepitopes determined by autoimmune responses associated with chronic arthritic attacks. The activation of macrophages and other defence cells in response to self‐epitopes as biomarkers in RA provides a better understanding of pathogenesis of disease and has led to the development of novel therapeutic approaches acting as potent inhibitors of these cells. Key findings The current review retrieved the various medicinal plants possessing an active phytoconstituents with anti‐inflammatory and antioxidant properties, which tends to be effective alternative approach over the synthetic drugs concerned with high toxic effects. The current available literature provided an evident data concluding that the active constituents like fatty acids, flavonoids, terpenes and sesquiterpene lactones attenuate the RA symptoms by targeting the inflammatory biomarkers involved in the pathogenesis of RA. Summary Despite the various synthetic treatment approaches targeting immune cells, cytokines improved the quality of life but still the drug management is challenging due to toxic and chronic teratogenic effects with anti‐arthritic drugs. The current review has elaborated the selected traditionally used herbal medicinal plants with phytoconstituents possessing anti‐inflammatory activity by suppressing the inflammatory biomarkers with lesser side effects and providing the future exploration of natural drug therapy for rheumatoid arthritis.

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Revealing the Active Constituents and Mechanisms of Semiliquidambar cathayensis Chang Roots against Rheumatoid Arthritis through Network Pharmacology, Molecular Docking, and in Vivo Experiment

Xia

Zeng

Wang

et al. 2022

Chemistry & Biodiversity

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Semiliquidambar cathayensis Chang roots (SC) are traditional Chinese medicine for treating rheumatoid arthritis (RA). However, the effect and potential mechanism of SC remain unclear. This study aims to reveal the anti-RA constituents and mechanisms of SC based on network pharmacology, molecular docking, and adjuvantinduced arthritis (AIA) model rat experiment. In this work, 9 potential active constituents, including kaempferol, quercetin, naringenin, paeoniflorin, catechin, fraxin, gentianin, hesperetin, and ellagic acid 3,3',4-trimethyl ether, in SC crossed 65 target genes of RA. In addition, 28 core targets were enriched in inflammation and others, among which interleukin-17 (IL-17) and tumor necrosis factor (TNF) were the major targets. The binding of bioconstituents with IL-17 and TNF were performed using molecular docking. Rat experiment demonstrated that the extract of SC restored body weight loss, reduced arthritis score and the indices of thymus and spleen, alleviated ankle joint histopathology, decreased the levels of rheumatoid factor (RF), C-reactive protein (CRP), IL-17, TNF-α, IL-1β, IL-6, cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and matrix metalloproteinase-2 (MMP-2), whereas elevated the levels of IL-4 and IL-10. Collectively, it was the first time to comprehensively reveal the anti-RA efficacy and mechanism of SC via suppressing the inflammatory pathway based on network pharmacology, molecular docking, and experimental verification, which provide chemical and pharmacological evidences for the clinical application of SC.

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Ribes orientale: A novel therapeutic approach targeting rheumatoid arthritis with reference to pro-inflammatory cytokines, inflammatory enzymes and anti-inflammatory cytokines

Cited by 46 publications

References 30 publications

Antiarthritic Potential of Comprehensively Standardized Extract of Alternanthera bettzickiana: In Vitro and In Vivo Studies

Antiarthritic Potential of Comprehensively Standardized Extract of Alternanthera bettzickiana: In Vitro and In Vivo Studies

Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis

Revealing the Active Constituents and Mechanisms of Semiliquidambar cathayensis Chang Roots against Rheumatoid Arthritis through Network Pharmacology, Molecular Docking, and in Vivo Experiment

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