Rhythmic Modulation of Theta Oscillations Supports Encoding of Spatial and Behavioral Information in the Rat Hippocampus

Molter, Colin; O’Neill, Joseph; Yamaguchi, Yoko; Hirase, Hajime; Leinekugel, Xavier

doi:10.1016/j.neuron.2012.06.036

Cited by 24 publications

(29 citation statements)

References 48 publications

(67 reference statements)

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“…The dynamics observed via these order parameters showed weak "chaotic" behaviors, but included extremely slow oscillations, which covered periods of the order of a few seconds, compared with the time scale of around 200 ms of fundamental coherent oscillations. Similar slow oscillations of a period of a few seconds have been observed in the hippocampal CA1 of rats in several sleeping and running states [37]. Another similar interesting behavior has been observed in the dynamics of the default mode network, although such a time scale of modulation spanned around 20 min [38].…”

Section: Redefined Neural Behaviors Via Ephaptic Couplings: a Tractabsupporting

confidence: 70%

Self-Organization with Constraints—A Mathematical Model for Functional Differentiation

Tsuda

Yamaguti

Watanabe

2016

Entropy

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This study proposes mathematical models for functional differentiations that are viewed as self-organization with external constraints. From the viewpoint of system development, the present study investigates how system components emerge under the presence of constraints that act on a whole system. Cell differentiation in embryos and functional differentiation in cortical modules are typical examples of this phenomenon. In this paper, as case studies, we deal with three mathematical models that yielded components via such global constraints: the genesis of neuronal elements, the genesis of functional modules, and the genesis of neuronal interactions. The overall development of a system may follow a certain variational principle.

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Section: Redefined Neural Behaviors Via Ephaptic Couplings: a Tractabsupporting

confidence: 70%

Self-Organization with Constraints—A Mathematical Model for Functional Differentiation

Tsuda

Yamaguti

Watanabe

2016

Entropy

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“…Importantly, there was a significant difference in the modulation of theta amplitude by acceleration and deceleration with deceleration explaining ∼16% of the variability in septal CA1, while acceleration explained only ∼2% (septal: t(4) = −9.453, p = .001; midseptotemporal: t(13) = −10.399, p <.0001; temporal: t(7) = −5.891, p = .001). It's important to note that the relationship between locomotor indices and theta amplitude has been demonstrated to depend upon the time-scale of analysis [52]. In order to address this concern, we computed power spectral density, coherence and partial correlation coefficients between theta amplitude and locomotor indices as a function of different locomotor speed filter cut-offs (Fig.…”

Section: Resultsmentioning

confidence: 99%

Theta Dynamics in Rat: Speed and Acceleration across the Septotemporal Axis

et al. 2014

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Theta (6–12 Hz) rhythmicity in the local field potential (LFP) reflects a clocking mechanism that brings physically isolated neurons together in time, allowing for the integration and segregation of distributed cell assemblies. Variation in the theta signal has been linked to locomotor speed, sensorimotor integration as well as cognitive processing. Previously, we have characterized the relationship between locomotor speed and theta power and how that relationship varies across the septotemporal (long) axis of the hippocampus (HPC). The current study investigated the relationship between whole body acceleration, deceleration and theta indices at CA1 and dentate gyrus (DG) sites along the septotemporal axis of the HPC in rats. Results indicate that whole body acceleration and deceleration predicts a significant amount of variability in the theta signal beyond variation in locomotor speed. Furthermore, deceleration was more predictive of variation in theta amplitude as compared to acceleration as rats traversed a linear track. Such findings highlight key variables that systematically predict the variability in the theta signal across the long axis of the HPC. A better understanding of the relative contribution of these quantifiable variables and their variation as a function of experience and environmental conditions should facilitate our understanding of the relationship between theta and sensorimotor/cognitive functions.

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“…Intrahippocampal Ab31-35 decreased the power of the theta rhythm, which was reversed by chronic melatonin treatments Working memory is organized by oscillatory processes in the theta and gamma frequency range (Lisman, 2010), and theta rhythm has been reported to associated with the spatial learning (Molter et al, 2012). We examined whether the theta rhythm in the CA1 region of hippocampus was affected by Ab31-35 and melatonin treatments by recording local field potentials.…”

Section: Synapsementioning

confidence: 99%

Melatonin protects against amyloid-β-induced impairments of hippocampal LTP and spatial learning in rats

Liu

Yang

et al. 2013

Synapse

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Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the elderly, leads to progressive loss of memory and cognitive deficits. Amyloid-β protein (Aβ) in the brain is thought to be the main cause of memory loss in AD. Melatonin, an indole hormone secreted by the pineal gland, has been reported to produce neuroprotective effects. We examined whether melatonin could protect Aβ-induced impairments of hippocampal synaptic plasticity, neuronal cooperative activity, and learning and memory. Rats received bilateral intrahippocampal injection of Aβ1-42 or Aβ31-35 followed by intraperitoneal application of melatonin for 10 days, and the effects of chronic melatonin treatment on in vivo hippocampal long-term potentiation (LTP) and theta rhythm and Morris water maze performance were examined. We showed that intrahippocampal injection of Aβ1-42 or Aβ31-35 impaired hippocampal LTP in vivo, while chronic melatonin treatment reversed Aβ1-42- or Aβ31-35-induced impairments in LTP induction. Intrahippocampal injection of Aβ31-35 impaired spatial learning and decreased the power of theta rhythm in the CA1 region induced by tail pinch, and these synaptic, circuit, and learning deficits were rescued by chronic melatonin treatment. These results provide evidence for the neuroprotective action of melatonin against Aβ insults and suggest a strategy for alleviating cognition deficits of AD.

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Rhythmic Modulation of Theta Oscillations Supports Encoding of Spatial and Behavioral Information in the Rat Hippocampus

Cited by 24 publications

References 48 publications

Self-Organization with Constraints—A Mathematical Model for Functional Differentiation

Self-Organization with Constraints—A Mathematical Model for Functional Differentiation

Theta Dynamics in Rat: Speed and Acceleration across the Septotemporal Axis

Melatonin protects against amyloid-β-induced impairments of hippocampal LTP and spatial learning in rats

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