Rhythmic auditory cues shape neural network recruitment in Parkinson's disease during repetitive motor behavior

Abstract

It is well established clinically that rhythmic auditory cues can improve gait and other motor behaviors in Parkinson's disease (PD) and other disorders. However, the neural systems underlying this therapeutic effect are largely unknown. To investigate this question we scanned people with PD and age‐matched healthy controls using functional magnetic resonance imaging (fMRI). All subjects performed a rhythmic motor behavior (right hand finger tapping) with and without simultaneous auditory rhythmic cues at two different speeds (1 and 4 Hz). We used spatial independent component analysis (ICA) and regression to identify task‐related functional connectivity networks and assessed differences between groups in intra‐ and inter‐network connectivity. Overall, the control group showed greater intra‐network connectivity in perceptual and motor related networks during motor tapping both with and without rhythmic cues. The PD group showed greater inter‐network connectivity between the auditory network and the executive control network, and between the executive control network and the motor/cerebellar network associated with the motor task performance. We interpret our results as indicating that the temporal rhythmic auditory information may assist compensatory mechanisms through network‐level effects, reflected in increased interaction between auditory and executive networks that in turn modulate activity in cortico‐cerebellar networks.

A Review on the Relationship Between Sound and Movement in Sports and Rehabilitation

“…Studies have also demonstrated that auditory cueing significantly improves upper-limb function after stroke by reducing movement variability and reliance on compensatory movements (e.g., Whitall et al, 2000; Thaut et al, 2002a,b; Luft et al, 2004; Jeong and Kim, 2007; Malcolm et al, 2009; Chen et al, 2016). It has been proposed that the continuous time reference provided by the rhythmic auditory cues facilitates movement retraining by priming the motor system, allowing movement anticipation and motor preparation (Thaut et al, 2015), and potentially bypassing damaged areas through the activation of alternative pathways (Hoemberg, 2005; Dalla Bella et al, 2017; Braunlich et al, 2018).…”

Development and Evaluation of a Novel Music-based Therapeutic Device for Upper Extremity Movement Training

“…Studies have consistently demonstrated that active music playing is effective to train upper extremity movement [35][36][37][38][39][40][41][42][43][44] due to crucial elements, such as the display of real-time multisensory information [54][55][56] and the use of metronome or beat-enhanced music to support movement training [49,62,63], which promote neuroplasticity [39,[57][58][59][60][61] and relevant changes in mood, arousal, and motivation [27,64]. In addition to all the elements involved in active music playing with traditional acoustic musical Beyond representing a new and effective methodology for the analysis of individual treatment goals and patient progress, the implementation of music technologies within the daily practice in neurorehabilitation could be paramount to transform the therapeutic process [67].…”

“…Research has also shown that the engagement of multisensory and motor networks during active music playing promotes neuroplastic changes in functional networks and structural components of the brain, which are crucial neurophysiological processes for neurologic recovery [39,[57][58][59][60][61]. Moreover, there is robust evidence that the use of metronome or beat-enhanced music is important to support movement training as the continuous-time reference provided by the rhythmic cues allow for movement anticipation and motor preparation, bypassing the movement timing dysfunction through the activation of alternate or spared neural pathways [49,62,63]. Finally, emotional-motivational aspects of music-making also play a signi cant role in the rehabilitating effects of music-based intervention through music-induced changes in mood, arousal, and motivation [27,64], with potential effects on perceived physical endurance and fatigue [30,65].…”

Papers arising from the 12th International Basal Ganglia Society Meeting. March 26th–30th 2017, Mérida, Yucatán, México

“…In a study in PD patients, Braunlich et al . () look at how rhythmic auditory cues shape neural network recruitment during repetitive motor behaviour. Using rodent models of PD, Aceves Buendia et al .…”

“…In their review, Stefani et al (2019) address the efficacy of deep brain stimulation of the subthalamic nucleus in PD, emphasising the importance of the severity and stage of the disease and Smith & Parr-Brownlie (2019), critically assess the new theory of PD aetiology relating to the relationship between the gastro-intestinal tract and the brain. In a study in PD patients, Braunlich et al (2019) look at how rhythmic auditory cues shape neural network recruitment during repetitive motor behaviour. Using rodent models of PD, Aceves Buendia et al (2019) We hope you find this Special Issue interesting and informative.…”