Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life

Hsiao, Hao‐Ming; Lin, Cheng Tao; Shen, Yung Kang; Chou, Tzu Yun; Hsu, Yen Yu

doi:10.3390/mi9010003

Cited by 7 publications

(10 citation statements)

References 51 publications

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“…Several finite element models were developed to evaluate the structural integrity and pulsatile fatigue life of a hybrid flow diverter subjected to loading conditions consistent with current manufacturing and clinical practice [16][17]. These included hybrid flow diverter expansion and its corresponding heat treatment during manufacturing, crimping of the hybrid flow diverter inside a catheter for delivery, its release into a blood vessel, and pulsatile fatigue life under systolic/diastolic cycles relative to heart beats.…”

Section: Manufacturing Simulationmentioning

confidence: 99%

Novel Hybrid Flow Diverter for Intracranial Aneurysm

Hsiao

Hung

Chou

et al. 2021

Preprint

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An intracranial aneurysm is a weakened area in the wall of a cerebral artery which causes abnormal localized ballooning of the blood vessel. As an aneurysm grows, it puts pressure on adjacent structures and may eventually rupture, leading to severe complications or even sudden death. The standard treatments for intracranial aneurysms include traditional craniotomy and endovascular coiling. The purpose of these treatments is to stop the blood flow to an aneurysm to reduce the risk of rupture. In recent years, another new device, "flow diverter", has gained popularity. It is placed in the parent artery to divert the blood flow away from the weakened area, isolating aneurysms from normal circulation. Although flow diverter stents have great potential, there remains clinical issues to be resolved. This paper proposes a unique hybrid flow diverter, the first of its kind in the world, for treatment of the intracranial aneurysm. The hybrid flow diverter is designed to have variable mesh densities, with the denser side facing an aneurysm to block the blood flow and the lighter side facing the artery to prevent stenosis. It is deployed in the main cerebral artery next to an aneurysm to divert the blood flow away from the weakened aneurysm. Simulation results showed that the hybrid flow diverter reduced the blood flow into an aneurysm by a whopping 75-95%. The residence time of the blood flow inside an aneurysm was 12.47 times longer with the hybrid flow diverter, which may trigger thrombogenic reaction to fill an aneurysm and thus reduce the risk of rupture.

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Section: Manufacturing Simulationmentioning

confidence: 99%

Novel Hybrid Flow Diverter for Intracranial Aneurysm

Hsiao

Hung

Chou

et al. 2021

Preprint

Self Cite

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“…Observational studies have shown promising results in the use of drug-eluting stents for ISR lesions [ 105 , 106 ]. A drug-eluting stent is a bare-metal stent with a drug coating [ 107 ] that minimizes neointimal hyperplasia and lessens repeat revascularization in BMS use. DES was developed through the application of different types and combinations of drugs as well as design materials and structural schemes.…”

Section: In-stent Restenosis Treatmentmentioning

confidence: 99%

“…DES design also has a key function in preventing neointima proliferation. No surface coating is required when a channel or depot stent (reservoir) is used, which may be loaded with a single, or else multiple, drugs for programmed delivery [ 107 , 130 , 131 ].…”

Section: In-stent Restenosis Treatmentmentioning

confidence: 99%

“…Observational studies have shown promising results in the use of drug-eluting stents for ISR lesions [105,106]. A drug-eluting stent is a bare-metal stent with a drug coating [107] that minimizes neointimal hyperplasia and lessens repeat revascularization in BMS use. Special heater-equipped catheters that are surgically inserted at the position of the stent [91], involve invasive procedures that constrain implementation of the technique as well as increases in treatment cost.…”

Section: Drug-eluting Stent Treatmentmentioning

confidence: 99%

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Health Care Monitoring and Treatment for Coronary Artery Diseases: Challenges and Issues

Alghrairi

Sulaiman

Mutashar

2020

Sensors

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In-stent restenosis concerning the coronary artery refers to the blood clotting-caused re-narrowing of the blocked section of the artery, which is opened using a stent. The failure rate for stents is in the range of 10% to 15%, where they do not remain open, thereby leading to about 40% of the patients with stent implantations requiring repeat procedure within one year, despite increased risk factors and the administration of expensive medicines. Hence, today stent restenosis is a significant cause of deaths globally. Monitoring and treatment matter a lot when it comes to early diagnosis and treatment. A review of the present stent monitoring technology as well as the practical treatment for addressing stent restenosis was conducted. The problems and challenges associated with current stent monitoring technology were illustrated, along with its typical applications. Brief suggestions were given and the progress of stent implants was discussed. It was revealed that prime requisites are needed to achieve good quality implanted stent devices in terms of their size, reliability, etc. This review would positively prompt researchers to augment their efforts towards the expansion of healthcare systems. Lastly, the challenges and concerns associated with nurturing a healthcare system were deliberated with meaningful evaluations.

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“…The simulated Von-Mises stress distributions of the multi-connector and single-connector stents are shown in Figure 8. In general, coronary stents use ductile materials that can achieve large deformation during balloon expansion [34]. They obey the Von-Mises stress criterion, expressed as σvon−mises=false[(σ1−σ2)2+(σ2−σ3)2+(σ3−σ1)2false]122≤σy where σ1, σ2, and σ3 are principle stresses.…”

Section: Simulationsmentioning

confidence: 99%

A Single-Connector Stent Antenna for Intravascular Monitoring Applications

Liu

Chen

Hsiao

2019

Sensors

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Recently, smart stents have been developed by integrating various sensors with intravascular stents for detecting vascular restenosis or monitoring intravascular biomedical conditions such as blood pressure or blood flow velocity. The information on biomedical signals is then transmitted to external monitoring systems via wireless communications. Due to the limited volumes of blood vessels and limited influence of blood flow, antennas with good radiation performance are required for intravascular applications. In this paper, we propose a stent antenna composed of multiple rings containing crowns and struts, where each ring is connected with one connector. Unlike a conventional stent, wherein each ring is connected with several connectors, the single connector prevents the random distribution of electrical current and thus achieves good radiation performance. The implantable stent antenna is designed for the frequency range of 2 to 3 GHz for minimum penetration loss in the human body and tissues. Mechanical FEM simulations were conducted to ensure that the mechanical deformation was within specific limits during balloon expansions. A prototype was fabricated with laser cutting techniques and its radiation performance experimentally characterized. It was demonstrated that the fabricated stent antenna had an omnidirectional radiation pattern for arbitrary receiving angles, a gain of 1.38 dBi, and a radiation efficiency of 74.5% at a resonant frequency of 2.07 GHz. The main contribution of this work was the manipulation of the current distributions of the stent for good EM radiation performances which needed to be further examined while inserted inside human bodies. These research results should contribute to the further development of implantable wireless communications and intravascular monitoring of biomedical signals such as blood pressure and blood flow velocity.

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Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life

Cited by 7 publications

References 51 publications

Novel Hybrid Flow Diverter for Intracranial Aneurysm

Novel Hybrid Flow Diverter for Intracranial Aneurysm

Health Care Monitoring and Treatment for Coronary Artery Diseases: Challenges and Issues

A Single-Connector Stent Antenna for Intravascular Monitoring Applications

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