Rhodotorulae are members of the family Cryptococcaceae, subfamily Rhodotorulodeae; although several species have been described, Rhodotorula glutinis and Rhodotorula rubra are the most common. Rhodotorula spp. are common saprophytes, widespread in nature. They have accidentally been isolated in human biological materials without pathological significance: they have been found in sputum and urine, especially in patients with severe debilitating diseases, in blood from patients with permanent intravenous devices, and in saliva obtained from denture wearers.Only rarely has an etiological role been attributed to these yeasts, and in all cases infection was clearly opportunistic (1-6). The following case is a R. glutinis-related meningitis in an immunocompetent patient that was successfully treated with amphotericin B.The patient was a 69-year-old white male (retired farmer) who was in his usual state of good health until 5 days before admission, when he developed persistent fever and headache. At physical examination, clear meningeal signs were observed, while the first hematochemical tests were not significant. Three separate blood cultures from a peripheral vein and a lumbar puncture (LP) were performed. Blood specimens were inoculated into Bactec Plus Aerobic/F and Bactec Anaerobic/F vials, which were placed in the BACTEC 9249 instrument and held for 8 days. The LP yielded clear cerebrospinal fluid (CSF), with a protein content of 0.82 g/liter, normal glucose concentration (and normal glycemia), and 30 lymphocytes/l. A Gram stain of the CSF was negative, as was a search for capsular antigens for Neisseria spp., pneumococcus, Haemophilus spp., and Cryptococcus neoformans; cultures of CSF for bacteria, mycobacteria, and fungi were also obtained. Empirical therapy with ceftriaxone, ampicillin, and acyclovir was started. Serologic tests for herpes, parotitis, enterovirus, human immunodeficiency virus, and treponemes were negative. Moreover, the Mantoux test, the chest x-ray, and a cerebral computerized tomography scan had no significant findings. After 3 days, both blood and CSF culture results were still negative, with the exception of the growth of one colony of R. glutinis in CSF. R. glutinis grew on Sabouraud dextrose agar containing chloramphenicol and gentamicin and was identified by the API 32-C System Biomerieux (API 32-C Bio-Merieux). The reported organism was considered a contaminate and therefore neglected. Because of the persisting symptoms, on day 5 of the hospital stay, a second LP was performed. The CSF analysis revealed a clear fluid, proteins at 0.9 g/liter, normal glucose (and normal glycemia), and 40 lymphocytes/l. Once again, after 3 days of incubation at 37°C, the Sabouraud dextrose agar showed the growth of three colonies of R. glutinis. On day 8 of the hospital stay, the previous therapy was stopped and the patient was treated intravenously with amphotericin B at dose of 1 mg/kg/day. In 3 days, the patient's temperature was back to normal, with a progressive improvement of clinical condition. W...