Rhodomyrtone inhibits lipase production, biofilm formation, and disorganizes established biofilm in Propionibacterium acnes

Wunnoo, Suttiwan; Saising, Jongkon; Voravuthikunchai, Supayang Piyawan

doi:10.1016/j.anaerobe.2016.12.002

Cited by 30 publications

(21 citation statements)

References 30 publications

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“…The numbers of the bacterial cells were reduced by at least 99% after treatment with rhodomyrtone within 24 h [75]. Especially, rhodomyrtone was observed to be able to prevent biofilm formation and to kill mature biofilms of S. mutans [76], S. aureus , S. epidermidis [77], and P. acnes [78].…”

Section: Pharmaceutical Propertiesmentioning

confidence: 99%

The Health Beneficial Properties of Rhodomyrtus tomentosa as Potential Functional Food

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2019

Biomolecules

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Rhodomyrtus tomentosa (Aiton) Hassk. is a flowering plant belonging to the family Myrtaceae, native to southern and southeastern Asia. It has been used in traditional Vietnamese, Chinese, and Malaysian medicine for a long time for the treatment of diarrhea, dysentery, gynecopathy, stomachache, and wound healing. Moreover, R. tomentosa is used to make various food products such as wine, tea, and jam. Notably, R. tomentosa has been known to contain structurally diverse and biologically active metabolites, thus serving as a potential resource for exploring novel functional agents. Up to now, numerous phenolic and terpenoid compounds from the leaves, root, or fruits of R. tomentosa have been identified, and their biological activities such as antioxidant, antibacterial, anti-inflammatory, and anticancer have been evidenced. In this contribution, an overview of R. tomentosa and its health beneficial properties was focused on and emphasized.

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Section: Pharmaceutical Propertiesmentioning

confidence: 99%

The Health Beneficial Properties of Rhodomyrtus tomentosa as Potential Functional Food

Ngo

2019

Biomolecules

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“…Furthermore, it could reduce biofilm formation by S. aureus and S. epidermidis , ensuing a reduction in the transcription signals of biofilm-related genes, with a different autolysin profile detectable in the treated cells [77,78]. Besides formation, effects on the disorganization of established biofilms have been recently documented in assays carried out on Propionibacterium acnes [86].…”

Section: Biological Activitiesmentioning

confidence: 99%

Structures and Bioactive Properties of Myrtucommulones and Related Acylphloroglucinols from Myrtaceae

et al. 2018

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Myrtaceae are a group of plants that include a number of renowned species used in ethnomedicine in many areas worldwide. Their valuable therapeutic properties have stimulated a fruitful research activity addressed to the identification of the bioactive components of their extracts yielding a great diversity of terpenes; polyphenols; and other exclusive products. Among the latter, starting with the discovery of myrtucommulone A from myrtle (Myrtus communis), a series of structurally-related acylphloroglucinol compounds have been characterized from several species that represent the basic active principles to be considered in view of possible drug development. Aspects concerning chemical and biological properties of these products are reviewed in the present paper.

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“…One such promising compound is the acylphloroglucinol rhodomyrtone, isolated from the leaves of the rose myrtle Rhodomyrtus tomentosa [ 5 ]. Rhodomyrtone is highly active against a broad range of Gram-positive bacteria, among which Bacillus , Enterococcus , Staphylococcus , and Streptococcus species, including clinical isolates and multi-resistant strains [ 5 , 6 ], and eradicates mature biofilms of Propionibacterium acnes [ 7 ], Staphylococcus aureus , and Staphylococcus epidermidis [ 8 ]. Rhodomyrtone is bactericidal and its minimal inhibitory concentrations are comparable to that of the last-resort antibiotics vancomycin and daptomycin [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity

et al. 2018

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The acylphloroglucinol rhodomyrtone is a promising new antibiotic isolated from the rose myrtle Rhodomyrtus tomentosa, a plant used in Asian traditional medicine. While many studies have demonstrated its antibacterial potential in a variety of clinical applications, very little is known about the mechanism of action of rhodomyrtone. Preceding studies have been focused on intracellular targets, but no specific intracellular protein could be confirmed as main target. Using live cell, high-resolution, and electron microscopy we demonstrate that rhodomyrtone causes large membrane invaginations with a dramatic increase in fluidity, which attract a broad range of membrane proteins. Invaginations then form intracellular vesicles, thereby trapping these proteins. Aberrant protein localization impairs several cellular functions, including the respiratory chain and the ATP synthase complex. Being uncharged and devoid of a particular amphipathic structure, rhodomyrtone did not seem to be a typical membrane-inserting molecule. In fact, molecular dynamics simulations showed that instead of inserting into the bilayer, rhodomyrtone transiently binds to phospholipid head groups and causes distortion of lipid packing, providing explanations for membrane fluidization and induction of membrane curvature. Both its transient binding mode and its ability to form protein-trapping membrane vesicles are unique, making it an attractive new antibiotic candidate with a novel mechanism of action.

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Rhodomyrtone inhibits lipase production, biofilm formation, and disorganizes established biofilm in Propionibacterium acnes

Cited by 30 publications

References 30 publications

The Health Beneficial Properties of Rhodomyrtus tomentosa as Potential Functional Food

The Health Beneficial Properties of Rhodomyrtus tomentosa as Potential Functional Food

Structures and Bioactive Properties of Myrtucommulones and Related Acylphloroglucinols from Myrtaceae

The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity

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