Abstract:In the last decade, a number of metal-catalyzed technologies for the functionalization of CÀ H bonds in carbonaceous aromatic substrates have been developed. However, similar reactions with aza-heteroaromatic precursors are more challenging and have been much less developed. Herein, we report for the first time catalytic formal cycloadditions of N,S-heterocycles featuring carboxylic acid substituents, with unsaturated partners (alkynes). The reaction, which works with different symmetrical and unsymmetrical al… Show more
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