“…Hence the methodology has proven to be a useful stratagem in the synthetic acquisition of several natural products (Nelson et al, 2000;Medeiros & Wood, 2010;Freeman, et al 2010). While not as extensively utilized or studied as the intermolecular variants, intramolecular interception of rhodium carbenoids by hydroxy nucleophiles can, nevertheless, afford an effective route to cyclic ethers and lactones (Paulissen et al, 1974;Moyer et al, 1985;Moody & Taylor, 1987;Heslin & Moody, 1988;Moody et al 1992;Sarabia-García et al, 1994;Padwa & Sá, 1999;Im et al, 2005). Indeed, studies by Moody and co-workers have shown that rhodium(II) acetate catalysed cyclization in diazoalcohols may even be employed as a practical method for accessing medium-ring oxacycles -oxepanes, in particular, wherein interference from competing C-H insertion reactions do not appear to be significant (Heslin & Moody, 1988;Davies et al, 1990).…”