Rhodium-catalyzed ring-opening reactions of heterobicyclic akenes with heteroarene nucleophiles: an experimental and computational investigation
Austin Pounder,
Eric Neufeld,
Leanne D. Chen
et al.
Abstract:We present an experimental and computational investigation into the rhodium-catalyzed ring-opening reactions of heterobicyclic alkenes with heteroarene nucleophiles. The reaction provides a facile route to trans-substituted dihydronaphthalen-1-ol and 1-amino-dihydronaphthalene products in up to a 95% yield as a single diastereomer. This reaction is 100% atom-economic and offers C–C bond formation without prior functionalization of the coupling partners. The mechanism and origins of selectivity were probed with… Show more
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