Rhodiola rosea (SHR-5), Part I

Ross, Stephanie Maxine

doi:10.1097/hnp.0000000000000014

Cited by 8 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SHR-5 has passed extensive toxicological studies and has been certified safe for both animals and humans [51, 52]. The typical amounts of Rhodiola rosea extract are 200 – 600 mg per day in capsules or tablets [14].…”

Section: Rhodiola Rosea L and Its Active Componentsmentioning

confidence: 99%

“…The typical amounts of Rhodiola rosea extract are 200 – 600 mg per day in capsules or tablets [14]. SHR-5 has been commercialized since 1985 and numerous clinical trials have been carried out with SHR-5 [25, 43–44, 51, 52]. Several clinical trials have shown that SHR-5 improved mental performance and attention in cognitive function in fatigue after single and repeated administration [44, 53, 54], and prevented physical, emotional, and mental exhaustion in patients with fatigue syndrome [43].…”

Section: Rhodiola Rosea L and Its Active Componentsmentioning

confidence: 99%

See 1 more Smart Citation

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Li¹,

Pham

Bui³

et al. 2017

Curr Pharmacol Rep

View full text Add to dashboard Cite

Purpose of review Rhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to non-specifically enhance the natural resistance of the body to both physical and behavior stresses for fighting fatigue and depression. We summarize the information with respect to the new pharmacological activities of Rhodiola rosea extracts and its underlying molecular mechanisms in this review article. Recent findings In addition to its multiplex stress-protective activity, Rhodiola rosea extracts have recently demonstrated its anti-aging, anti-inflammation, immunostimulating, DNA repair and anti-cancer effects in different model systems. Molecular mechanisms of Rhodiola rosea extracts’s action have been studied mainly along with one of its bioactive compounds, salidroside. Both Rhodiola rosea extracts and salidroside have contrast molecular mechanisms on cancer and normal physiological functions. For cancer, Rhodiola rosea extracts and salidroside inhibit the mTOR pathway and reduce angiogenesis through down-regulation of the expression of HIF-1α/HIF-2α. For normal physiological functions, Rhodiola rosea extracts and salidroside activate the mTOR pathway, stimulate paracrine function and promote neovascularization by inhibiting PHD3 and stabilizing HIF-1α proteins in skeletal muscles. In contrast to many natural compounds, salidroside is water-soluble and highly bioavailable via oral administration and concentrated in urine by kidney excretion. Summary Rhodiola rosea extracts and salidroside can impose cellular and systemic benefits similar to the effect of positive lifestyle interventions to normal physiological functions and for anti-cancer. The unique pharmacological properties of Rhodiola rosea extracts or salidroside deserve further investigation for cancer chemoprevention, in particular for human urinary bladder cancer.

show abstract

Section: Rhodiola Rosea L and Its Active Componentsmentioning

confidence: 99%

Section: Rhodiola Rosea L and Its Active Componentsmentioning

confidence: 99%

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Li¹,

Pham

Bui³

et al. 2017

Curr Pharmacol Rep

View full text Add to dashboard Cite

show abstract

“…Rhodiola rosea L. (Fam: Crassulaceae) is commonly known as Rhodiola , roseroot, arctic root, or golden root. The yellow-flowered herbaceous perennial grows naturally at high altitudes in dry sandy soil on sea cliffs and in the crevices of mountain rocks of Arctic regions of Europe, Asia (primarily Siberia), and in the eastern coastal regions of North America 1. Traditionally, Rhodiola rosea has been used for centuries to increase physical endurance, work productivity, longevity, and resistance to high-altitude sickness and to treat fatigue, depression, anemia, impotence, gastrointestinal ailments, infections, and nervous system disorders 2…”

mentioning

confidence: 99%