Rhodiola rosea polysaccharides-based nanoparticles loaded with DOX boosts chemo-immunotherapy for triple-negative breast cancer by re-educating Tumor-associated macrophages

Xiong, Yingxia; Li, Nan; Han, Miaomiao; Ye, Fan; Liu, Tian; Ye, Hanyi; Zheng, Tingting; Wu, Jin-jia; Liu, Ying; Zhang, Yun; Zhang, Yinghua; Lv, Shaohua; Dong, Zihui

doi:10.1016/j.ijbiomac.2023.124110

Cited by 9 publications

(10 citation statements)

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“…Cell cycle was performed as previously described [ 39 , 40 ]. Briefly, B16 cells were seeded in 6-well plates at 1.0 × 10 6 cells per well and mediated by various concentrations of CPPSs.…”

Section: Methodsmentioning

confidence: 99%

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Isolation, Purification, and Structural Characterization of Polysaccharides from Codonopsis pilosula and Their Anti-Tumor Bioactivity by Immunomodulation

Xiong

et al. 2023

Pharmaceuticals

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The activity of polysaccharides is usually related to molecular weight. The molecular weight of polysaccharides is critical to their immunological effect in cancer therapy. Herein, the Codonopsis polysaccharides of different molecular weights were isolated using ultrafiltration membranes of 60- and 100-wDa molecular weight cut-off to determine the relationship between molecular weight and antitumor activities. First, three water-soluble polysaccharides CPPS-I (<60 wDa), CPPS-II (60–100 wDa), and CPPS-III (>100 wDa) from Codonopsis were isolated and purified using a combination of macroporous adsorption resin chromatography and ultrafiltration. Their structural characteristics were determined through chemical derivatization, GPC, HPLC, FT–IR, and NMR techniques. In vitro experiments indicated that all Codonopsis polysaccharides exhibited significant antitumor activities, with the tumor inhibition rate in the following order: CPPS-II > CPPS-I > CPPS-III. The treatment of CPPS-II exhibited the highest inhibition rate at a high concentration among all groups, which was almost as efficient as that of the DOX·HCL (10 μg/mL) group at 125 μg/mL concentration. Notably, CPPS-II demonstrated the ability to enhance NO secretion and the antitumor ability of macrophages relative to the other two groups of polysaccharides. Finally, in vivo experiments revealed that CPPS-II increased the M1/M2 ratio in immune system regulation and that the tumor inhibition effect of CPPS-II + DOX was superior to that of DOX monotherapy, implying that CPPS-II + DOX played a synergistic role in regulating the immune system function and the direct tumor-killing ability of DOX. Therefore, CPPS-II is expected to be applied as an effective cancer treatment or adjuvant therapy.

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Section: Methodsmentioning

confidence: 99%

“…The antitumor effect was performed by the previously published work [ 39 ]. Briefly, the tumor volume and body weight were recorded at 2-day intervals.…”

Section: Methodsmentioning

confidence: 99%

Isolation, Purification, and Structural Characterization of Polysaccharides from Codonopsis pilosula and Their Anti-Tumor Bioactivity by Immunomodulation

Xiong

et al. 2023

Pharmaceuticals

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“…Rhodiola rosea is a perennial shrub in the sedum family. Rhodiola rosea polysaccharides (RHPs) are among the main R. rosea . Given that RHPs have diverse therapeutic effects, such as immune regulation as well as antioxidant and antitumor effects bioactive components, RHPs have been used as a biomaterial for delivering chemotherapeutic drugs.…”

Section: The Biomaterials Science Of Tnbcmentioning

confidence: 99%

“…Given that RHPs have diverse therapeutic effects, such as immune regulation as well as antioxidant and antitumor effects bioactive components, RHPs have been used as a biomaterial for delivering chemotherapeutic drugs. Xiong et al used folic acid and stearic acid to modify the backbone of RHPs to obtain the self-assembly and tumor-targeting behavior …”

Section: The Biomaterials Science Of Tnbcmentioning

confidence: 99%

Nanoparticle-Mediated Immunotherapy in Triple-Negative Breast Cancer

Wang,

Huang,

Chen

et al. 2024

ACS Biomater. Sci. Eng.

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Triple-negative breast cancer (TNBC) is an aggressive subtype with the worst prognosis and highest recurrence rates. The treatment choices are limited due to the scarcity of endocrine and HER2 targets, except for chemotherapy. However, the side effects of chemotherapy restrict its long-term usage. Immunotherapy shows potential as a promising therapeutic strategy, such as inducing immunogenic cell death, immune checkpoint therapy, and immune adjuvant therapy. Nanotechnology offers unique advantages in the field of immunotherapy, such as improved delivery and targeted release of immunotherapeutic agents and enhanced bioavailability of immunomodulators. As well as the potential for combination therapy synergistically enhanced by nanocarriers. Nanoparticles-based combined application of multiple immunotherapies is designed to take the tactics of enhancing immunogenicity and reversing immunosuppression. Moreover, the increasing abundance of biomedical materials holds more promise for the development of this field. This review summarizes the advances in the field of nanoparticle-mediated immunotherapy in terms of both immune strategies for treatment and the development of biomaterials and presents challenges and hopes for the future.

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“…This has significantly improved the encapsulation of the hydrophobic drug DOX. Experimental results showed that the delivery efficiency and the ability to regulate macrophage polarization were both enhanced by using this co-modified nanoparticle ( Xiong et al, 2023 ). Furthermore, functional siRNA drug systems based on FA were effectively validated.…”

Section: Targeting Tams: a Promising Spot Owing To Their Vital Roles ...mentioning

confidence: 99%

Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

Zheng,

Jiang,

et al. 2023

Front. Bioeng. Biotechnol.

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Targeting tumor-associated macrophages (TAMs) has emerged as a promising approach in cancer therapy. This article provides a comprehensive review of recent advancements in the field of nanomedicines targeting TAMs. According to the crucial role of TAMs in tumor progression, strategies to inhibit macrophage recruitment, suppress TAM survival, and transform TAM phenotypes are discussed as potential therapeutic avenues. To enhance the targeting capacity of nanomedicines, various approaches such as the use of ligands, immunoglobulins, and short peptides are explored. The utilization of live programmed macrophages, macrophage cell membrane-coated nanoparticles and macrophage-derived extracellular vesicles as drug delivery platforms is also highlighted, offering improved biocompatibility and prolonged circulation time. However, challenges remain in achieving precise targeting and controlled drug release. The heterogeneity of TAMs and the variability of surface markers pose hurdles in achieving specific recognition. Furthermore, the safety and clinical applicability of these nanomedicines requires further investigation. In conclusion, nanomedicines targeting TAMs hold great promise in cancer therapy, offering enhanced specificity and reduced side effects. Addressing the existing limitations and expanding our understanding of TAM biology will pave the way for the successful translation of these nano-therapies into clinical practice.

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Rhodiola rosea polysaccharides-based nanoparticles loaded with DOX boosts chemo-immunotherapy for triple-negative breast cancer by re-educating Tumor-associated macrophages

Cited by 9 publications

References 50 publications

Isolation, Purification, and Structural Characterization of Polysaccharides from Codonopsis pilosula and Their Anti-Tumor Bioactivity by Immunomodulation

Isolation, Purification, and Structural Characterization of Polysaccharides from Codonopsis pilosula and Their Anti-Tumor Bioactivity by Immunomodulation

Nanoparticle-Mediated Immunotherapy in Triple-Negative Breast Cancer

Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

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