Rhodiola rosea does not reduce in vivo inflammatory activity after continuous endurance exercise

Lin, C.-H.; Hsu, Chih-Chieh; Lin, Shuhai; Hsu, Mei‐Chich

doi:10.1016/j.scispo.2018.10.006

Cited by 5 publications

(28 citation statements)

References 3 publications

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“…It is believed that RR can reduce various stressors caused by chemical and biological factors, however, this effects is not related to inflammatory cytokines. A study ( 6 ) with 12 heathy subjects found that serum levels of inflammatory indicators, such as IL-1β, IL-6, TNF-α, and CRP, were not reduced in the RR group (400 mg/day, 8 days) compared with the placebo group after continuous endurance exercise (30-min run at 75% VO 2max ). Another study ( 13 ), with 48 runners competing in a marathon, reported that total blood leukocyte counts, IL-6, IL-8, IL-10, MCP-1, G-CSF, CRP, and eHSP72 all increased significantly, however, no significant differences were found for the RR group (600 mg/day, 30 days) compared with the placebo group ( P = 0.526).…”

Section: Resultsmentioning

confidence: 99%

“…The extraction methods as well as the quantification criteria differed significantly from one manufacturer to another. The Rhodiola rosea supplement was standardized to a minimum of 3 total Rosavins and 1% total Salidroside ( 6 , 9 – 11 , 13 – 15 ). However, some studies did not show the content of rosavins and salidroside in Rhodiola rosea ( 7 , 8 , 12 ).…”

Section: Resultsmentioning

confidence: 99%

“…Compared with the placebo group, there was a tendency for blood creatine kinase (CK) levels to decrease in the Rhodiola group 72 h after continuous exercise (208.2 ± 32.7 vs. 136.7 ± 13.8 U/L, P < 0.05) ( 6 ). In another study, the CK levels showed a significant reduction for the RR group in comparison with the placebo group in rest time (19.35 ± 2.96 vs. 34.26 ± 5.95 U/L, P < 0.05), acme (23.50 ± 3.96 vs. 37.19 ± 7.29 U/L, P < 0.05) and 30 min recovery time samples (25.70 ± 5.24 vs. 35.52 ± 4.20 U/L, P < 0.05) .…”

Section: Resultsmentioning

confidence: 99%

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Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review

Deng

et al. 2022

Front. Nutr.

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Rhodiola rosea (Golden Root Extract; RR) is an herbaceous perennial, which is native to high altitude areas, such as East Asia, Central Asia, Siberia, and North America. It has been studied for its positive pharmacological effects on health. However, only a handful of studies have evaluated the effects of RR as an exercise supplement for sport and physical activity. The aim of this study was to evaluate whether Rhodiola can be used as a supplement to improve human exercise ability. Studies were reviewed in accordance with the PRISMA guidelines and conducted between August and November, 2021. Databases searched included Cochrane, Embase, Web of Science, PubMed and East View Universal Database. Related terms were combined with keywords and MeSH subject headings using the corresponding Boolean operators: Rhodiola rosea, arctic root, roseroot, golden root, hongjingtian, and sports and exercise. A total of 10 papers were reviewed. Most of the studies reported that RR supplementation has a positive effect on athletic ability and sports performance, and no obvious adverse reactions were reported. Subjects taking RR showed a reduction in pain and muscle damage after exercise training, improved skeletal muscle damage, enhanced antioxidant capacity thereby reducing oxidative stress, reduced RPE scores, and improved athletic explosive power, but did not reduce the rating of perceived exertion (RPE) scores. RR appears to act as a safe and effective supplementation for sport and exercise.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review

Deng

et al. 2022

Front. Nutr.

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“…For the other risks of bias, approximately 17% of studies of R . rosea were judged to have high risk of bias due to the industry sponsorship issue [ 38 ] or the lack of sample size calculation along with small sample size and nonsignificant results [ 28 , 31 , 46 ]. For both studies of R .…”

Section: Resultsmentioning

confidence: 99%

“…ere are studies of R. rosea which have a high risk of bias in domains of performance bias, detection bias, attrition bias, or reporting bias with percentages not exceeding 9%. For the other risks of bias, approximately 17% of studies of R. rosea were judged to have high risk of bias due to the industry sponsorship issue [38] or the lack of sample size calculation along with small sample size and nonsignificant results [28,31,46]. For both studies of R. crenulata and R. wallichiana, no high risk of bias was found during the assessment.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

Quality Evaluation of Randomized Controlled Trials of Rhodiola Species: A Systematic Review

Chen

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Rhodiola is a worldwide used medicinal plant for its various medicinal functions, and the number of randomized controlled trials (RCTs) of Rhodiola is increasing in recent years. This study aims to evaluate the reporting quality and risk of bias of the current RCT reports of different Rhodiola species. Methods. Six databases including Embase, PubMed, Web of Science, the Cochrane Library, ClinicalTrial.gov, and China National Knowledge Infrastructure were searched to identify RCTs that used Rhodiola as a single intervention and were published in English or Chinese from inception to December 2020. The Consolidated Standards of Reporting Trials (CONSORT) 2010 statement was used as the checklist for assessment, and a scoring system was applied to the evaluation of RCTs. Score 0 represents no reporting or inadequate reporting, and score 1 represents adequate reporting. The risk of bias of the included studies was also assessed using the Cochrane Risk of Bias tool. Results. A total of 39 RCTs were included in this study, including 23 RCTs of Rhodiola rosea (R. rosea), 8 RCTs of Rhodiola crenulata (R. crenulata), and 8 RCTs of Rhodiola wallichiana (R. wallichiana). None of the included studies met all the CONSORT statement criteria, and the reporting quality of RCTs of the three Rhodiola species was all generally poor. Based on the risk of bias assessment, the majority of included studies were judged to have an unclear risk of bias in most domains due to inadequate reporting. Conclusions. There is inadequate reporting among the included RCTs of different Rhodiola species, and RCTs of Rhodiola with higher reporting quality and better methodological quality are needed.

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Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials

Sanz‐Barrio,

Noreen,

Gilsanz‐Estebaranz

et al. 2023

Phytotherapy Research

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The aim of this systematic review was to determine whether the supplementation with Rhodiola rosea (RR), an herb that has been used for centuries for its various properties, can have an effect on muscle damage and physical performance. The databases PubMed, Web of Science, and Cochrane Library were used to find studies published until March 2023. Randomized controlled trials, healthy participants, and no use of other supplements. The search strategy was conducted by two independent reviewers, and specific information was extracted from the selected studies. Thirteen studies were included with 263 participants (198 men and 65 women between 18 and 65 years old). Two studies followed acute supplementation, 5 chronic, and 6 combined both. The results were heterogenous, having 11 studies with some positive effects, while 2 studies show no effect in variables such as rating of perceive exertion, heart rate, antioxidant capacity, blood lactate, creatine kinase, or C‐reactive protein. Two limitations were found, firstly, the difference between supplementation and exercise protocols, and secondly, the existence of unclear or high risk of bias in most of the studies included. Acute supplementation with RR has a positive effect on endurance performance and rating of perceived exertion (RPE). Chronic supplementation has a positive effect on anaerobic exercise performance, but not endurance exercise performance. Chronic supplementation may positively impact muscle damage during exercise. However, more high‐quality studies are needed to firmly establish the clinical efficacy of RR.

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Rhodiola rosea does not reduce in vivo inflammatory activity after continuous endurance exercise

Cited by 5 publications

References 3 publications

Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review

Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review

Quality Evaluation of Randomized Controlled Trials of Rhodiola Species: A Systematic Review

Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials

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