Rhodiola: An Overview of Phytochemistry and Pharmacological Applications

Bhardwaj, Pushpender; Bhardwaj, Garima; Raghuvanshi, Rinky; Thakur, Mayank; Kumar, Raj; Chaurasia, O. P.

doi:10.1007/978-981-10-8291-7_5

Cited by 9 publications

(2 citation statements)

References 72 publications

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“…In recent years, TTM has received extensive attention worldwide owing to its unique advantages in terms of preventing and treating cancer. TTM can directly inhibit the growth of cancer cells, induce apoptosis, and suppress tumor growth through multi-target pathways ( Yadav et al., 2017 ; Bhardwaj et al., 2018 ; Tao et al., 2019 ). In addition, TTM combined with radiotherapy or chemotherapy can significantly reduce adverse reactions and enhance the patient’s immunity and quality of life ( Liu et al., 2016a ; Liu et al., 2016b ; Colapietro et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Traditional Tibetan Medicine in Cancer Therapy by Targeting Apoptosis Pathways

et al. 2020

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Cancer is a leading cause of death around the world. Apoptosis, one of the pathways of programmed cell death, is a promising target for cancer therapy. Traditional Tibetan medicine (TTM) has been used by Tibetan people for thousands of years, and many TTMs have been proven to be effective in the treatment of cancer. This paper summarized the medicinal plants with anticancer activity in the Tibetan traditional system of medicine by searching for Tibetan medicine monographs and drug standards and reviewing modern research literatures. Forty species were found to be effective in treating cancer. More importantly, some TTMs ( e.g ., Ophiocordyceps sinensis , Phyllanthus emblica L. and Rhodiola kirilowii (Regel) Maxim.) and their active ingredients ( e.g. , cordycepin, salidroside, and gallic acid) have been reported to possess anticancer activity by targeting some apoptosis pathways in cancer, such as Bcl-2/Bax, caspases, PI3K/Akt, JAK2/STAT3, MAPK, and AMPK. These herbs and natural compounds would be potential drug candidates for the treatment of cancer.

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Section: Introductionmentioning

confidence: 99%

Traditional Tibetan Medicine in Cancer Therapy by Targeting Apoptosis Pathways

et al. 2020

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“…are among the major medicinal plants which were previously studied and reported to have biologically relevant compounds that have valuable effects against the diseases like hypertension, stress, inflammation and tumor. 4,5 The tremendous therapeutic potential of the flora is substantially due to bioactive second-ary metabolites found in these plants, which in turn credit the plants with tolerance to harsh climatic conditions in Ladakh. 3 Campanulaceae family includes around 600 species of 40 genera and Codonopsis is one of the member in these genera.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Antioxidant Activity Study of Methanol Extract of Stems and Roots of Codonopsis clematidea from Trans-himalayan Region

Bhardwaj¹,

Thakur²,

Kapoor³

et al. 2019

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Aim: The present report aimed to study the therapeutic and phytochemical properties of stems and roots of trans-himalayan plant Codonopsis clematidea. Material and Methods: The crude samples of stems and roots were explored for their chlorophyll, carotenoid and carbohydrate content in order to understand the matrix of these two plant parts. The extraction of phytochemicals was carried out by three different methods viz. sonication, maceration and soxhlet in methanol to identify the best extraction method. Further, analysis of Total Flavonoid Content (TFC) and Total Polyphenolic Content (TPC) were carried out using rutin trihydrate and gallic acid as a reference standard. Antioxidant capacity was estimated using three methods viz. 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assay and Ferric Reducing Antioxidant Power (FRAP) assay. In addition to this, GC-MS analysis was also performed for the identification of volatile constituents of Methanol Extract of Stems (MES) and Methanol Extract of Roots (MER). Results: The MES and Dimethylsulfoxide Extract of Stems (DES) were found to have higher Chlorophyll a (Ch a) content in comparison to Chlorophyll b (Ch b) and Carotenoids (C ca). Carbohydrate profile showed that stems and roots have the highest content of fructose in comparison to other sugar moieties. The soxhlet method showed the highest percentage extractive yield in the stems as well as roots. Results revealed that the MES showed higher antioxidant potential as compared to the MER. A correlation has also found to exist between the results of TPC, TFC and antioxidant assays, since TPC and TFC are key constituents responsible for the antioxidant potential. Conclusion: These results have been found to suggest the richness of MES in natural phenols, flavonoids and antioxidants. Further, study should be conducted over identification and characterization of compounds present in the extract.

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