RhoA signaling through platelet P2Y1 receptor controls leukocyte recruitment in allergic mice

Amison, Richard T.; Momi, Stefania; Morris, Abigail; Manni, Giorgia; Keir, Sandra; Gresele, Paolo; Page, Clive; Pitchford, Simon

doi:10.1016/j.jaci.2014.09.032

Cited by 62 publications

(101 citation statements)

References 68 publications

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“…Specifically, platelet depletion has been shown to reduce the allergen-induced infiltration of eosinophils, lymphocytes, monocytes/macrophages, and neutrophils into the lungs of rodents. 27,[36][37][38] In this regard circulating platelet-leukocyte complexes occur at far greater frequency after both spontaneous asthma attacks in a biphasic manner or after allergen challenge in the clinic (Fig 2). 13,17,37 The possible significance of these platelet-leukocyte complexes is presumably to act as a ''priming'' step to promote efficient leukocyte adhesion to the vascular endothelium because leukocytes attached to platelets display more of the aM subunit (CD11b) of the aMb2 integrin macrophage 1 antigen (CD11b/CD18) than circulating leukocytes not attached to platelets.…”

Section: Pulmonary Leukocyte Recruitment Is Platelet Dependentmentioning

confidence: 97%

Role of platelets in allergic airway inflammation

Idzko

Pitchford

Page

2015

Journal of Allergy and Clinical Immunology

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Section: Pulmonary Leukocyte Recruitment Is Platelet Dependentmentioning

confidence: 97%

Role of platelets in allergic airway inflammation

Idzko

Pitchford

Page

2015

Journal of Allergy and Clinical Immunology

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“…Accordingly, one recent report described an important contribution of the platelet P2Y 1 receptor to inflammation of the airways in allergic mice through its role in the formation of the platelet-leukocyte complexes required for leukocyte recruitment to the lung tissue. 44 However, it is difficult to firmly establish from these data whether the platelet receptor was entirely responsible or whether the P2Y 1 receptors present on other cell types were also involved in allergic asthma.…”

Section: P2y 1 Receptor In Inflammationmentioning

confidence: 98%

“…35 In sharp contrast, a recent study reported no involvement of P2Y 12 in allergic inflammation in ovalbumin-challenged mice, whereas the platelet P2Y 1 receptor appeared to be pivotal (see below). 44 Obviously, there are conflicting data concerning the part played by the P2Y 12 receptor in asthma, and whether the discrepancies might be related to differences in the mouse models of allergic inflammation or to the use of P2Y 12 receptor antagonists versus P2Y 12 −/− mice will require further investigation.…”

Section: 41mentioning

confidence: 99%

Purinergic Receptors in Thrombosis and Inflammation

Hechler

Gachet

2015

ATVB

142

101

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Abstract-Under various pathological conditions, including thrombosis and inflammation, extracellular nucleotide levels may increase because of both active release and passive leakage from damaged or dying cells. Once in the extracellular compartment, nucleotides interact with plasma membrane receptors belonging to the P2 purinergic family, which are expressed by virtually all circulating blood cells and in most blood vessels. In this review, we focus on the specific role of the 3 platelet P2 receptors P2Y 1 , P2Y 12 , and P2X 1 in hemostasis and arterial thrombosis. Beyond platelets, these 3 receptors, along with the P2Y 2 , P2Y 6 , and P2X 7 receptors, constitute the main P2 receptors mediating the proinflammatory effects of nucleotides, which play important roles in various functions of circulating blood cells and cells of the vessel wall. Each of these P2 receptor subtypes specifically contributes to chronic or acute vascular inflammation and related diseases, such as atherosclerosis, restenosis, endotoxemia, and sepsis. The potential for therapeutic targeting of these P2 receptor subtypes is also discussed.

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“…P2Y 1 receptors control leukocyte recruitment in allergic inflammation in mice. 198 Review articles have been published on various aspects of purinergic signaling in thrombosis and inflammation, including the use of the P2Y 12 receptor antagonists clopidogrel, prasugrel, cangrelor, and ticagrelor 199,200 ; platelets and inflammation 201 ; and P2Y receptor polymorphisms and disease. 202 …”

Section: Ischemiamentioning

confidence: 99%

Purinergic Signaling in the Cardiovascular System

Burnstock

2017

Circulation Research

324

295

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Abstract:There is nervous control of the heart by ATP as a cotransmitter in sympathetic, parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in the brain control heart activities and vagal cardiovascular reflexes involve purines. Adenine nucleotides and nucleosides act on purinoceptors on cardiomyocytes, AV and SA nodes, cardiac fibroblasts, and coronary blood vessels. Vascular tone is controlled by a dual mechanism. ATP, released from perivascular sympathetic nerves, causes vasoconstriction largely via P2X1 receptors. Endothelial cells release ATP in response to changes in blood flow (via shear stress) or hypoxia, to act on P2 receptors on endothelial cells to produce nitric oxide, endothelium-derived hyperpolarizing factor, or prostaglandins to cause vasodilation. ATP is also released from sensory-motor nerves during antidromic reflex activity, to produce relaxation of some blood vessels. Purinergic signaling is involved in the physiology of erythrocytes, platelets, and leukocytes. ATP is released from erythrocytes and platelets, and purinoceptors and ectonucleotidases are expressed by these cells. P1, P2Y 1 , P2Y 12 , and P2X1 receptors are expressed on platelets, which mediate platelet aggregation and shape change. Long-term (trophic) actions of purine and pyrimidine nucleosides and nucleotides promote migration and proliferation of vascular smooth muscle and endothelial cells via P1 and P2Y receptors during angiogenesis, vessel remodeling during restenosis after angioplasty and atherosclerosis. The involvement of purinergic signaling in cardiovascular pathophysiology and its therapeutic potential are discussed, including heart failure, infarction, arrhythmias, syncope, cardiomyopathy, angina, heart transplantation and coronary bypass grafts, coronary artery disease, diabetic cardiomyopathy, hypertension, ischemia, thrombosis, diabetes mellitus, and migraine. (Circ Res. 2017;120:207-228.

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RhoA signaling through platelet P2Y1 receptor controls leukocyte recruitment in allergic mice

Cited by 62 publications

References 68 publications

Role of platelets in allergic airway inflammation

Role of platelets in allergic airway inflammation

Purinergic Receptors in Thrombosis and Inflammation

Purinergic Signaling in the Cardiovascular System

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