RhoA activation promotes glucose uptake to elevate proliferation in MAPK inhibitor resistant melanoma cells
Vasanth Siruvallur Murali,
Divya Rajendran,
Tadamoto Isogai
et al.
Abstract:Cutaneous melanomas harboring a B-RafV600Emutation are treated with immune check point inhibitors or kinase inhibitor combination therapies relying on MAPK inhibitors (MAPKi) Dabrafenib and Trametinib (Curti and Faries, 2021). However, cells become resistant to treatments over the timespan of a few months. Resistance to MAPKi has been associated with adoption of an aggressive amoeboid phenotype characterized by elevated RhoA signaling, enhanced contractility and thick cortical filamentous actin (F-actin) struc… Show more
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