2015
DOI: 10.1124/pr.115.010595
|View full text |Cite
|
Sign up to set email alerts
|

Rho Kinases in Health and Disease: From Basic Science to Translational Research

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
137
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 162 publications
(138 citation statements)
references
References 212 publications
1
137
0
Order By: Relevance
“…By keeping MYPT-1 inactive, ROCK triggers MLC phosphorylation, cytosolic Ca +2 level increase and as a result it's contraction. 13 AMPKs vascular effect is the opposite of this. In contrast to ROCKs effect, AMPK activation increases the activity of eNOS in arterial smooth muscle.…”
Section: Rho-kinase and Adenosine Monophosphate-activated Protein Kinmentioning
confidence: 95%
See 3 more Smart Citations
“…By keeping MYPT-1 inactive, ROCK triggers MLC phosphorylation, cytosolic Ca +2 level increase and as a result it's contraction. 13 AMPKs vascular effect is the opposite of this. In contrast to ROCKs effect, AMPK activation increases the activity of eNOS in arterial smooth muscle.…”
Section: Rho-kinase and Adenosine Monophosphate-activated Protein Kinmentioning
confidence: 95%
“…ROCK are the first and most important effectors of the RhoA. 13,14 There are two isoforms of ROCK, namely, ROCK1 and ROCK2.…”
Section: Rho-kinase Pathwaymentioning
confidence: 99%
See 2 more Smart Citations
“…Mounting evidence has shown that ROCKs act as determinant molecular switches controlling several critical cellular functions, such as proliferation and apoptosis, cytoskeletal rearrangement, cell adhesion and migration, inflammation, and reactive oxygen species formation [8][9][10]. Fasudil, a potent and selective ROCK inhibitor, showed clinical effectiveness and safety in the treatments of cardiovascular and cerebrovascular diseases, such as aneurysmal subarachnoid hemorrhage and myocardial ischemia [11,12].…”
Section: Introductionmentioning
confidence: 99%