Rho Kinase Regulates Induction of T-Cell Immune Dysfunction in Abdominal Sepsis

Hasan, Zirak; Palani, Karzan; Zhang, Songen; Lepsenyi, Mattias; Hwaiz, Rundk; Rahman, Milladur; Syk, Ingvar; Jeppsson, Bengt; Thorlacius, Henrik

doi:10.1128/iai.00126-13

Cited by 20 publications

(13 citation statements)

References 46 publications

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“…It was reported that CLP evoked apoptosis and decreased proliferation in splenic CD 4+ T cells (Hasan et al, 2013). Lymphocyte apoptosis was increased in CD 4+ and CD 8+ T cells, B cells (CD20), and NK cells (CD 56+ ) in septic versus nonseptic patients.…”

Section: T-lymphocyte Apoptosismentioning

confidence: 98%

Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis

et al. 2015

Molecular Immunology

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Section: T-lymphocyte Apoptosismentioning

confidence: 98%

Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis

et al. 2015

Molecular Immunology

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“…This entire process is generally dependent on Rho/ROCK signaling (Hirase et al 2001;Adamson et al 2002;Schaible et al 2013). Certain functions of immune cells, such as neutrophil migration, neutrophil adhesion to epithelial cells, and T-cell immunity are also regulated by Rho/ROCK signaling (Saito et al 2002;Yagi et al 2006;Hasan et al 2013). Interestingly, Rho/ROCK signaling-mediated extracellular environment may modulate pro-inflammatory (M1) vs. pro-healing (M2) activation (McWhorter et al 2013).…”

Section: Inflammationmentioning

confidence: 99%

Modulation of microenvironment for controlling the fate of periodontal ligament cells: the role of Rho/ROCK signaling and cytoskeletal dynamics

Yamamoto

Ugawa

Kawamura

et al. 2017

J. Cell Commun. Signal.

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“…NME2 is a negative regulator of Rho activity. Inhibition of Rho kinase activity causes a decrease in apoptosis and enhanced proliferation of CD4 T cells, an important group of cells involved with immune system (Hasan et al, 2013). Interferon-activated, dimerized signal transducers and activators of transcription (STAT2) gene are latent cytoplasmic transcription factors that bind to importins via a non-classical nuclear localization signals (NLSs) and also regulates the expression of genes involved in host immune defense (Levy and Darnell, 2002).…”

Section: Discussionmentioning

confidence: 99%

Unravelling the genetic components involved in the immune response of pigs vaccinated against influenza virus

Zanella

Gava²,

Peixoto³

et al. 2015

Virus Research

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A genome-wide association study for immune response to influenza vaccination in a crossbred swine population was conducted. Swine influenza is caused by influenza A virus (FLUAV) which is considered one of the most prevalent respiratory pathogens in swine worldwide. The main strategy used to control influenza in swine herds is through vaccination. However, the currently circulating FLUAV subtypes in swine are genetically and antigenically diverse and their interaction with the host genetics poses a challenge for the production of efficacious and cross-protective vaccines. In this study, 103 pigs vaccinated with an inactivated H1N1 pandemic virus were genotyped with the Illumina PorcineSNP60V2 BeadChip for the identification of genetic markers associated with immune response efficacy to influenza A virus vaccination. Immune response was measured based on the presence or absence of HA (hemagglutinin) and NP (nucleoprotein) antibodies induced by vaccination and detected in swine sera by the hemagglutination inhibition (HI) and ELISA assays, respectively. The ELISA test was also used as a measurement of antibody levels produced following the FLUAV vaccination. Associations were tested with x(2) test for a case and control data and using maximum likelihood method for the quantitative data, where a moderate association was considered if p<5×10(-5). When testing the association using the HI results, three markers with unknown location and three located on chromosomes SSCX, SSC14 and SSC18 were identified as associated with the immune response. Using the response to vaccination measured by ELISA as a qualitative and quantitative phenotype, four genomic regions were associated with immune response: one on SSC12 and three on chromosomes SSC1, SSC7, and SSC15, respectively. Those regions harbor important functional candidate genes possibly involved with the degree of immune response to vaccination. These results show an important role of host genetics in the immune response to influenza vaccination. Genetic selection for pigs with better response to FLUAV vaccination might be an alternative to reduce the impact of influenza virus infection in the swine industry. However, these results should to be validated in additional populations before its use.

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Rho Kinase Regulates Induction of T-Cell Immune Dysfunction in Abdominal Sepsis

Cited by 20 publications

References 46 publications

Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis

Calcium-sensing receptor in the T lymphocyte enhanced the apoptosis and cytokine secretion in sepsis

Modulation of microenvironment for controlling the fate of periodontal ligament cells: the role of Rho/ROCK signaling and cytoskeletal dynamics

Unravelling the genetic components involved in the immune response of pigs vaccinated against influenza virus

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