Abstract:Background:
Subcortical white matter lesions are exceedingly common in cerebral small vessel disease and lead to significant cumulative disability without an available treatment. Here, we tested a rho-kinase inhibitor on functional recovery after focal white matter injury.
Methods:
A focal corpus callosum lesion was induced by stereotactic injection of N
5
-(1-iminoethyl)-L-ornithine in mice. Fasudil (10 mg/kg)… Show more
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