Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development

Meyer, Tobias; Schwesinger, Catherine; Sampogna, Rosemary V.; Vaughn, Duke A.; Stuart, Robert O.; Steer, Dylan; Bush, Kevin T.; Nigám, Sanjay K.

doi:10.1111/j.1432-0436.2006.00102.x

Cited by 51 publications

(49 citation statements)

References 33 publications

(41 reference statements)

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“…The beneficial effects of ROCK inhibition are further supported by work published by Unbekandt et al who could show that transient ROCK inhibition allows cells from disaggregated embryonic kidneys to form ureteric bud and nephron epithelia (Unbekandt & Davies, 2010). Moreover, one last positive effect of ROCK inhibition related to the prevention of IRI mentioned might be that ROCK inhibition promotes cell survival in human stem cells (Watanabe et al 2007) and is able to reduce apoptosis in conventional embryonic kidney culture (Meyer et al 2006). …”

Section: Rock Inhibition In Ischemia Reperfusion Injurysupporting

confidence: 63%

ROCK Inhibition – A New Therapeutic Avenue in Kidney Protection

Reuter¹,

Kentrup²,

Büssemaker³

2011

Kidney Transplantation - New Perspectives

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Section: Rock Inhibition In Ischemia Reperfusion Injurysupporting

confidence: 63%

ROCK Inhibition – A New Therapeutic Avenue in Kidney Protection

Reuter¹,

Kentrup²,

Büssemaker³

2011

Kidney Transplantation - New Perspectives

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“…Under these conditions, basement membrane thickness remains constant, as opposed to varying (as in untreated rudiments), which indicates that basement membrane contraction has not occurred (Moore et al, 2005). Another recent study linked ROCK activity to ureteric bud development in the kidney (Meyer et al, 2006), but it remains to be seen whether cytoskeletal tension or ECM plasticity is involved. ROCK-mediated control of cytoskeletal tension could therefore be a general mechanism regulating branching morphogenesis.…”

Section: Ecm Remodeling In Branching Morphogenesismentioning

confidence: 98%

Extracellular matrix dynamics in development and regenerative medicine

Daley

Peters

Larsen

2008

Journal of Cell Science

864

716

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The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. Far from being a static structure, the ECM is constantly undergoing remodeling – i.e. assembly and degradation – particularly during the normal processes of development, differentiation and wound repair. When misregulated, this can contribute to disease. ECM assembly is regulated by the 3D environment and the cellular tension that is transmitted through integrins. Degradation is controlled by complex proteolytic cascades, and misregulation of these results in ECM damage that is a common component of many diseases. Tissue engineering strives to replace damaged tissues with stem cells seeded on synthetic structures designed to mimic the ECM and thus restore the normal control of cell function. Stem cell self-renewal and differentiation is influenced by the 3D environment within the stem cell niche. For tissue-engineering strategies to be successful, the intimate dynamic relationship between cells and the ECM must be understood to ensure appropriate cell behavior.

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“…Rho-associated coiled-coil containing kinase (ROCK) regulates epithelial morphogenesis in the lung (Moore et al, 2005), kidney (Meyer et al, 2006;Michael et al, 2005) and salivary gland (Daley et al, 2009). During salivary gland and lung development, ROCK promotes basement membrane remodeling to mediate changes in tissue shape through a myosin II-dependent pathway that requires cellular contractility (Daley et al, 2009;Moore et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity

et al. 2012

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SUMMARYThe basement membrane is crucial for epithelial tissue organization and function. However, the mechanisms by which basement membrane is restricted to the basal periphery of epithelial tissues and the basement membrane-mediated signals that regulate coordinated tissue organization are not well defined. Here, we report that Rho kinase (ROCK) controls coordinated tissue organization by restricting basement membrane to the epithelial basal periphery in developing mouse submandibular salivary glands, and that ROCK inhibition results in accumulation of ectopic basement membrane throughout the epithelial compartment. ROCK-regulated restriction of PAR-1b (MARK2) localization in the outer basal epithelial cell layer is required for basement membrane positioning at the tissue periphery. PAR-1b is specifically required for basement membrane deposition, as inhibition of PAR-1b kinase activity prevents basement membrane deposition and disrupts overall tissue organization, and suppression of PAR1b together with ROCK inhibition prevents interior accumulations of basement membrane. Conversely, ectopic overexpression of wild-type PAR-1b results in ectopic interior basement membrane deposition. Significantly, culture of salivary epithelial cells on exogenous basement membrane rescues epithelial organization in the presence of ROCK1 or PAR-1b inhibition, and this basement membrane-mediated rescue requires functional integrin 1 to maintain epithelial cell-cell adhesions. Taken together, these studies indicate that ROCK1/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.

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Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development

Cited by 51 publications

References 33 publications

ROCK Inhibition – A New Therapeutic Avenue in Kidney Protection

ROCK Inhibition – A New Therapeutic Avenue in Kidney Protection

Extracellular matrix dynamics in development and regenerative medicine

ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity

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