Rho iso-alpha acids from hops inhibit the GSK-3/NF-κB pathway and reduce inflammatory markers associated with bone and cartilage degradation

Konda, Veera Reddy; Desai, Anuradha; Darland, Gary; Bland, Jeffrey S.; Tripp, Matthew L.

doi:10.1186/1476-9255-6-26

Cited by 24 publications

(14 citation statements)

References 34 publications

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“…These preliminary IAA pharmacokinetic studies demonstrated that IAA compounds can be detected and suggests that the structurally similar reduced IAA may also be able to be targeted. Furthermore, there have been toxicity [19] and pharmacokinetic studies investigating reduced IAA, particularly RIAA and TIAA, due to their possible medicinal properties such as weight loss, antidiabetic, anti-carcinogenic and anti-inflammatory [7,8,[20][21][22][23]. Of these, two studies detected RIAA and TIAA in New Zealand white rabbits [7], and one measured RIAA in humans [8], confirming those reduced IAA groups examined were indeed bioavailable.…”

Section: Introductionmentioning

confidence: 65%

Pharmacokinetics of reduced iso-α-acids in volunteers following clear bottled beer consumption

Rodda

Gerostamoulos

Drummer

2015

Forensic Science International

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Section: Introductionmentioning

confidence: 65%

Pharmacokinetics of reduced iso-α-acids in volunteers following clear bottled beer consumption

Rodda

Gerostamoulos

Drummer

2015

Forensic Science International

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“…For MMP-13, IL-1 or TNF treatment causes an increase in the human chondrosarcoma cell line SW1353 after 20-24 h [8]. Similarly, NO donor treatment also causes an increase in human and bovine chondrocytes after 24 h [14] and after 16 h [21].…”

Section: Discussionmentioning

confidence: 95%

c-Jun N-terminal kinase and nuclear factor κB mediate nitric oxide-induced expression of matrix metalloproteinase-13

Yang

2010

International Orthopaedics (SICOT)

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The purpose of this study was to investigate the mechanism of expression of matrix metalloproteinase-13 (MMP-13) induced by nitric oxide (NO). Human chondrocytes (HCs) were stimulated with a NO donor (MAHMANONOate), then mitogen-activated protein kinases' (MAPKs) and nuclear factor κB' (NF-κB) activations and MMP-13′ expression were assayed by Western blot analysis. Additionally, the intracellular signalling of NO was investigated using the inhibitors of MAPKs and NF-κB. NO-induced MMP-13 expression was not suppressed by extracellular signal-regulated kinase (ERK) inhibitor (PD98059) or inhibitors of p38 kinase (SB203580), but was inhibited by a c-jun terminal kinase (JNK) inhibitor (SP600125) and inhibitors of NF-κB (SN-50). Additionally, SP600125 treatment reduced NF-κB activation, but SN-50 treatment did not significantly affect JNK activation. These results suggest that NO induces MMP-13 expression by JNK and NF-κB activation in HCs.

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“…In comparison with formalin or hydrogen peroxide, the existing USFDA-approved chemicals used for fungal control during egg incubation, hops is much safer for humans. Hops has "gen-erally regarded as safe" (GRAS) status (Konda et al 2009) and has few negative consequences on human health. Infrequently, there are reports of typically mild allergic reactions as a result of frequent skin contact or inhalation (Cookson and Lawton 1953;Newmark 1978;Śpiewak et al 2001;Góra et al 2004;Van Cleemput et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Natarajan et al (2008) indicated surprise that the antimicrobial activity of hops was not used more widely in nonbrewing applications. This has started to change, however, and hops has been evaluated for potential use in livestock rearing (Cornelison et al 2006;Siragusa et al 2008;Wang et al 2010), food preservation (Larson et al 1996), human health (Zanoli and Zavatti 2008;Konda et al 2009), and human personal care (Dumas et al 2009). This initial study demonstrates for the first time that hops has possible utility as an antifungal agent for eggs in production aquaculture.…”

Section: Discussionmentioning

confidence: 99%

Initial Investigations of Hops as a Salmonid Egg Fungicide

et al. 2012

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Hatchery incubation of salmonid eggs typically requires the use of chemical fungicides that possess potential negative effects on human health or the environment. Strobiles from the hops Humulus lupulus plant have exhibited antimicrobial properties in nonaquaculture situations. This study investigated the use of hops as an alternative zoosporic fungal treatment with three experiments. In the first experiment, dried strobiles from wild variety hops were ground and placed at two concentrations in petri dishes containing sesame seeds and hatchery water containing Saprolegnia diclina. There was a positive relationship between the concentrations of hops and the amount of time elapsed before the observance of zoosporic fungal infestation. In subsequent experiments, the antimycotic activity of two concentrations of commercially available Summit variety hop pellets were evaluated using dead Chinook salmon Oncorhynchus tshawytscha eggs in vertical-flow incubation trays. In the second experiment, which involved static treatments of either 24 or 48 g of hop pellets wrapped in cheesecloth, zoosporic fungi appeared on the eggs in all the treatments at the same time and developed at the same rate. In the third experiment, the cheesecloth was eliminated and hop pellets were placed directly in the incubation trays at amounts of either 224 g for the entire duration of the experiment, or 112 g initially with 88 g of hops added after 3 d. Zoosporic fungi did not appear on the dead eggs in any of the hops treatment trays until 72 h after water mold was observed on the controls. Hops also delayed complete egg infestation by 72 h. Results from these experiments indicate for the first time the potential use of both wild and commercially available hops to control zoosporic fungi on incubating salmonid eggs.

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Rho iso-alpha acids from hops inhibit the GSK-3/NF-κB pathway and reduce inflammatory markers associated with bone and cartilage degradation

Cited by 24 publications

References 34 publications

Pharmacokinetics of reduced iso-α-acids in volunteers following clear bottled beer consumption

Pharmacokinetics of reduced iso-α-acids in volunteers following clear bottled beer consumption

c-Jun N-terminal kinase and nuclear factor κB mediate nitric oxide-induced expression of matrix metalloproteinase-13

Initial Investigations of Hops as a Salmonid Egg Fungicide

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