2015
DOI: 10.4161/21541248.2014.991233
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Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections

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Cited by 13 publications
(10 citation statements)
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References 123 publications
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“…By reducing microtubule de-polymerisation this allows Salmonella to promote tubular lysosomes (endosomal tubules), in conjunction with other proteins such as SifA, increasing fusion events with endosomal vesicles carrying in nutrients from the extracellular environment. Rho GTPases are a common target of bacterial pathogens [ 49 , 50 ] and further work is required to determine whether SseJ’s effect on cellular microtubules is mediated through RhoA or RhoC.…”
Section: Discussionmentioning
confidence: 99%
“…By reducing microtubule de-polymerisation this allows Salmonella to promote tubular lysosomes (endosomal tubules), in conjunction with other proteins such as SifA, increasing fusion events with endosomal vesicles carrying in nutrients from the extracellular environment. Rho GTPases are a common target of bacterial pathogens [ 49 , 50 ] and further work is required to determine whether SseJ’s effect on cellular microtubules is mediated through RhoA or RhoC.…”
Section: Discussionmentioning
confidence: 99%
“…Once internalized, they hijack the molecular machinery of the infected cell not only to prevent their own degradation in the phagocytic pathway, but also to create a favorable intracellular environment for growth and replication. Cristi an Quintero, Juli an Gambarte, Mar ıa Damiani 39 focus their attention on the role of Rho proteins on four curable, sexually transmitted infections, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and Treponema pallidum.…”
Section: Rho Gtpase As Pathogen Targets; Therapeutic Perspectivesmentioning
confidence: 99%
“…The antibacterial cathelicidin LL-37 increases the cellular stiffness of lung epithelial cells resulting in reduced uptake of Pseudomonas aeruginosa (Byfield et al, 2011). Actin polymerization, focal adhesion signaling, and Rho GTPase activity play important roles in the infection of a wide variety of bacteria (Galan & Zhou, 2000;Prashar et al, 2018;Quintero, Tudela, & Damiani, 2015); thus, while the effects of tissue stiffness on bacterial pathogenesis have thus far not been well studied, we hypothesize that matrix mechanics may be a critical regulator for a range of microbial infections.…”
Section: Role Of Mechanical Forces In Bacterial Pathogenesismentioning
confidence: 98%