“…Overexpression of TPPP1 in cells promotes MT polymerization and an increase in MT acetylation, whereas introduction of TPPP1 RNAi reduces MT acetylation [43]. Phosphorylation of TPPP1 by Rho-associated coiled-coil kinase (ROCK) and cyclin-dependent kinase 1 (CDK1) impairs the interaction between TPPP1 and HDAC6, which, in turn, results in increased HDAC6 activity followed by a decrease in cell motility and an increase in cell proliferation, respectively [46,47]. Moreover, a broad spectrum of regulators, which directly interact with and inhibit HDAC6 tubulin deacetylase activity or aggresome formation ability, has been well documented, including paxillin [48], CYLD [49,50], dysferlin [51], Mdp3 [52], p62 [53] and RanBPM [54].…”