Rhnull with naturally occurring antibody

The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX‐47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues

“…The high-frequency blood group antigen Ok", defined by human antisera and mAb Tra-1-85 [17,18], is carried on a glycoprotein of 35-69 kDa (the Ok" gp) and is expressed on red cells, leukocytes, and a variety of cell lines [18]. The Ok(a-) blood group phenotype is very rareonly eight families with Ok(a-) members are known and all are Japanese [19,201. The widely distributed gp of Mr 50000 defined by mAb A103 [21], whose gene MSK20 also maps to chromosome 19~13.2-pter [22], is identical to the Oka gp [20].…”

Rh and RHAG Blood Group Systems

“…Anti -Rh29 has been made by people with Rh null of both types, though not all Rh null individuals make anti -Rh29 when immunised; two Rh null sisters had no Rh antibody although they had a total of nine children. Antibodies in the sera of two Rh null donors who had received no known immunising stimulus behaved as anti -Hr o , reacting with all red cell samples save those of Rh null and D --phenotypes [530,531] . Antibodies in the sera of two Rh null donors who had received no known immunising stimulus behaved as anti -Hr o , reacting with all red cell samples save those of Rh null and D --phenotypes [530,531] .…”

Short duplication within theRHCEgene associated with an in cis deletedRHDcausing aRhnullamorph phenotype in an immunized pregnant woman with anti‐Rh29

“…The degree of anemia in Rh null subjects varies from mild to moderate in different individuals and even in the same individual. Rh null individuals rarely develop antibodies without stimulation and most cases occur in response to pregnancy or transfusion. Subjects with Rh null RBCs readily produce alloantibodies to high‐prevalence Rh antigens.…”