Rhizoma polygonati from Mount Tai: nutritional value and usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and chronic and hidden hunger

Nurtay, Lazzat; Sun, Qinglei; Mu, Chenglin; Cao, Zhongshan; Wang, Qian; Liang, Zongsuo; Ma, Cuiping; Li, Xugang; Amin, Amr; Xie, Yingqiu

doi:10.1097/hm9.0000000000000008

Cited by 18 publications

(5 citation statements)

References 32 publications

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“…Moreover, integration with the traditional Chinese Medicine Huangjing, and EGFR inhibitor for treatment by applying the phosphatase activity of nanocale Huangjing of nanozyme, as we recently proposed in cancer cells [ 27 ], would also be promising. Thus, cancer patients may benefit the integration method if undergoing cancer precision therapy when traveling, with the target inhibitors as repurposed or rehabilitation medicine during Omicron circulation [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Omicron N501Y mutation among SARS-CoV-2 lineages: In silico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicine

Kazybay

Ahmad

et al. 2022

Travel Medicine and Infectious Disease

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Variants of SARS-CoV-2 lineages including the most recently circulated Omicron, and previous pandemic B.1.351, B.1.1.7, which have been public concerns, contain a N501Y mutation located in the spike receptor binding domain. However, the potential interactions with host cells linking N501Y mutation to pathogenic relevance remain elusive. Recently, we and others report that kinases such as PI3K/AKT signaling is essential in SARS-CoV-2 entry. Here we analyzed the predicted potential kinases interacting with the mutation. Bioinformatics tools including structure-prediction based molecular docking analysis were applied. We found kinases such as EGFR might potentially act as new acceptors involving the N501Y mutation binding through possible phosphorylation at Y501 and enhanced affinity in certain variants. To our surprise, the Omicron receptor binding domain harboring N501Y mutation did not enhance binding to EGFR which might be due to the mutations of charged polar to uncharged polar side chains located on the interaction interfaces. Similarly, potent gains of phosphorylation in B.1.351 and B.1.1.7 by mutations were predicted and interaction networks were analyzed with enrichment of pathways. Given kinases might be elevated in cancer patients, the N501Y mutation containing lineages may be possibly much more infectious and additional care for cancer management might be taken into consideration by precision prevention, therapy or recovery.

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Section: Resultsmentioning

confidence: 99%

Omicron N501Y mutation among SARS-CoV-2 lineages: In silico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicine

Kazybay

Ahmad

et al. 2022

Travel Medicine and Infectious Disease

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“…Mainly, anti-inflammatory and antioxidant agents may play a crucial role in preventing DOX-induced cardiotoxicity ( Sahasrabudhe et al, 2018 ). Several natural products demonstrated high potency against DOX-induced cardiotoxicity ( El-Kharrag et al, 2017 ; Nurtay et al, 2021 ; Xie et al, 2021 ). Induced cardiotoxicity has been prevented by natural product nanoparticles ( Al Shamsi et al, 2004 ; Amin and Mahmoud-Ghoneim 2011 ; Baig et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

Al-Kuraishy

Al-Hussaniy²,

Al-Gareeb

et al. 2022

Front. Pharmacol.

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Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies. However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity. Therefore, the present study aimed to assess the cardioprotective effects of P. ginseng C. A. Mey, febuxostat, and their combination against DOX-induced cardiotoxicity. Thirty-five Sprague Dawley male rats were used in this study. The animals were randomly divided into five groups, with seven rats per group. The control group received normal saline, the induced group received DOX only, and the treated group received P. ginseng, febuxostat, and their combination before DOX treatment. Biomarkers of acute cardiac toxicity were assessed in each group. Results showed that treatment with the combination of febuxostat and P. ginseng before DOX led to a significant improvement in the biomarkers of acute DOX-induced cardiotoxicity. In conclusion, the combination of P. ginseng and febuxostat produced more significant cardioprotective effects against DOX-induced cardiotoxicity when compared to either P. ginseng or febuxostat when used alone. The potential mechanism of this combination was mainly mediated by the anti-inflammatory and antioxidant effects of P. ginseng and febuxostat.

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“…Polygonati Rhizoma, first recorded in "MingYi BieLu" written by Hongjing Tao of the Liang Dynasty in China, has been a TCMs and nutritious food for over 2000 years [11]. Polygonatum kingianum Coll.…”

Section: Introductionmentioning

confidence: 99%

Oral Supplementation of Dragon Power® Polygonatum had Beneficial Effects on Testosterone's Relationship with Cardiorespiratory Fitness and Erection: a Double-Blind, Placebo-Controlled Study

Chiang

2024

JNFP

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As age increases, the concentration of testosterone (male hormone) in the body gradually decreases, causing various aging conditions, such as physical strength. Among them, the Chinese herbal medicine Polygonatum kingianum (PK) can very well improve physical strength and resist fatigue. The purpose of this study is to explore whether PK can increase testosterone's relationship with cardiorespiratory fitness and erection. Subjects were randomly assigned to either the placebo group (n=25) or the PK group (n=25). Subjects were required to ingest 50 mL of the test product daily for a duration of 4 weeks. Cardiorespiratory endurance and blood biochemical values were analyzed at week 0, week 2, and week 4. After the subjects took it for 4 weeks, the results showed that PK extract drink increased testosterone 14% compared to the placebo group, and without any side effects on liver and kidney function. After taking PK extract drink for 2 and 4 weeks, the cardiorespiratory endurance index was significantly improved by 3.7% and 6.2%, and phosphodiesterase 5 (PDE5) expression was significantly decreased by 23.3% and 28.9% compared to placebo group. PK extract drink increased testosterone and was harmless to humans, and improved physical strength, erectile function.

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Rhizoma polygonati from Mount Tai: nutritional value and usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and chronic and hidden hunger

Cited by 18 publications

References 32 publications

Omicron N501Y mutation among SARS-CoV-2 lineages: In silico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicine

Omicron N501Y mutation among SARS-CoV-2 lineages: In silico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicine

Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

Oral Supplementation of Dragon Power® Polygonatum had Beneficial Effects on Testosterone's Relationship with Cardiorespiratory Fitness and Erection: a Double-Blind, Placebo-Controlled Study

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