Rhipicephalus microplus: An overview of vaccine antigens against the cattle tick

Pereira, Diogo Fonseca Soares; Ribeiro, Helen Silva; Gonçalves, Ana Alice Maia; Silva, Augusto Ventura da; Lair, Daniel Ferreira; Oliveira, Diana Souza de; Boas, Diego Fernandes Vilas; Conrado, Ingrid dos Santos Soares; Leite, Jaqueline Costa; Barata, Luccas Miranda; Reis, Pedro Campos Carvalhaes; Mariano, Reysla Maria da Silveira; Santos, Thaiza Aline Pereira; Coutinho, Danielle Carvalho Oliveira; Gontijo, Nelder de Figueiredo; Araújo, Ricardo Nascimento; Galdino, Alexsandro Sobreira; Paes, Paulo Ricardo de Oliveira; Melo, Marília Martins; Nagem, Ronaldo Alves Pinto; Dutra, Walderez Ornelas; Silveira-Lemos, Denise da; Rodrigues, Daniel Sobreira; Giunchetti, Rodolfo Cordeiro

doi:10.1016/j.ttbdis.2021.101828

Cited by 29 publications

(30 citation statements)

References 127 publications

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“…The current measures for control of ticks rely on habitat management, such as local removal of vegetation and animal hosts, and chemical control with acaricides applied to vegetation or most often to animals. Promising vaccines for cattle have been developed for Rhipicephalus microplus , the most important livestock tick for transmitting the protozoan responsible for bovine babesiosis (Pereira et al 2022), but evaluation of antigens for the development of vaccines against other tick vectors of cattle diseases of major veterinary importance is necessary. An mRNA vaccine targeting the blacklegged tick , Ixodes scapularis , is a promising candidate against the spread of Borrelia burgdorferi , the main Lyme disease agent (Sajid et al 2021).…”

Section: Classical Vector Control Methodsmentioning

confidence: 99%

Transgenic approaches in medical entomology: 2022 highlights

Simões

2023

Journal of Medical Entomology

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Transgenesis has emerged as a powerful tool to control arthropod vectors and the diseases they transmit. Here, we highlight the latest developments on transgenic approaches in ticks, Anopheles and Aedes mosquitoes, based on recent findings and significant papers from 2022. We survey topics ranging from population replacement, population suppression, gene drive, sex ratio distortion, public engagement and capacity building, and gene editing in ticks. While presenting these advancements, we discuss the current challenges surrounding the application of arthropod transgenesis for the development of novel vector control strategies.

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Section: Classical Vector Control Methodsmentioning

confidence: 99%

Transgenic approaches in medical entomology: 2022 highlights

Simões

2023

Journal of Medical Entomology

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“…R. microplus is predicted to have a global economic impact of roughly $10 billion per year. As a result, several efforts to develop tick control technologies have been launched (Pereira et al, 2022). Here, we used isolated mitochondria to investigate how the mitochondrial metabolic state affects polyP metabolism in tick mitochondria.…”

Section: Introductionmentioning

confidence: 99%

Inorganic polyphosphate's role in energy production and mitochondrial permeability transition pore opening in tick mitochondria

Domingues¹,

Moraes

Fonseca

et al. 2023

Arch Insect Biochem Physiol

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Inorganic polyphosphate (polyP) is a biopolymer composed of phosphoanhydride‐linked orthophosphate molecules. PolyP is engaged in a variety of cellular functions, including mitochondrial metabolism. Here, we examined the effects of polyP on electron transport chain enzymes and F1Fo ATP synthase in tick embryos during embryonic development. The study found that polyPs containing medium and long chains (polyP15 and polyP65) enhanced the activity of complex I, complex II, complex III, and F1Fo ATP synthase, while short polyP chains (polyP3) had no effect. The study also examined the activity of exopolyphosphatases (PPX) in various energy‐demand situations. PPX activity was stimulated when ADP concentrations are high, characterizing a low‐energy context. When complexes I–III and F1Fo ATP synthase inhibitors were added in energized mitochondria, PPX activity decreased, whereas the mitochondrial uncoupler FCCP had no impact on PPX activity. Additionally, the study investigated the effect of polyP on mitochondrial swelling, finding that polyP causes mitochondrial swelling by increasing calcium effects on the mitochondrial permeability transition pore. The findings presented here to increase our understanding of the function of polyP in mitochondrial metabolism and its relationship to mitochondrial permeability transition pore opening in an arthropod model.

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“…In Uganda, the most common tick species are the brown ear ticks ( Rhipicephalus appendiculatus ), blue ticks ( R. decoloratus ), bont ticks ( Amblyomma variegatum ), and red ticks ( R. evertsi ) [ 2 , 3 , 4 , 5 , 6 ]. Ticks are responsible for USD 1.1 billion in annual losses, resulting from livestock deaths due to tick-borne pathogens, related morbidity, costly but unreliable treatment of tick-borne diseases, acaricide resistance, blood loss from hosts, and tick-associated tissue damages, among other factors [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…As stated by cattle farmers, if cattle are not sprayed with a potent acaricide for two weeks, tick infestation varies between 30–45 ticks per animal. The three-host brown ear tick, R. appendiculatus , is the most common tick infesting cattle in Uganda and other southern and southeastern African countries [ 2 , 6 ]. As observed in the field, it is common to find hares acting as reservoir hosts on cattle farms adhering to strict tick control.…”

Section: Introductionmentioning

confidence: 99%

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Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda

Kabi¹,

Dhikusooka²,

Matovu³

et al. 2022

Vaccines

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A collaboration program was established between the group of Health and Biotechnology (SaBio) of the IREC Institute of Game and Wildlife Research (CSIC-UCLM-JCCM, Spain) and the National Agricultural Research Organization of Uganda (NARO) for the development of vaccines for the control of cattle ticks in Uganda. Controlled pen trials identified a tick protective antigen, Rhipicephalus appendiculatus Subolesin, and a cross-species-effective vaccine formulation. As the next step, a controlled vaccine field trial has been approved by Ugandan state regulatory authorities, the Uganda National Council for Science and Technology (UNCST) and the National Drug Authority (NDA), to evaluate the efficacy and effectiveness of the vaccine formulation for the control of cattle tick infestations under field conditions. The results of this trial may lead to the approval of the vaccine for application in Uganda to improve cattle health and production while reducing the use of acaricides.

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Rhipicephalus microplus: An overview of vaccine antigens against the cattle tick

Cited by 29 publications

References 127 publications

Transgenic approaches in medical entomology: 2022 highlights

Transgenic approaches in medical entomology: 2022 highlights

Inorganic polyphosphate's role in energy production and mitochondrial permeability transition pore opening in tick mitochondria

Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda

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