Rhinoviruses

Stott, E J; Killington, R A

doi:10.1146/annurev.mi.26.100172.002443

Cited by 64 publications

(31 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rhinoviruses, the major causative agents of common colds (Stott & Killington, 1972), are important human pathogens. Indeed it has been suggested that rhinovirus infections may be the most common of all the acute infections of man (Gwaltney, 1975).…”

Section: Introductionmentioning

confidence: 99%

Neutralization epitopes of human rhinovirus type 2

Appleyard

Russell

Clarke

et al. 1990

Journal of General Virology

View full text Add to dashboard Cite

Fourteen neutralizing monoclonal antibodies recognizing human rhinovirus (HRV) type 2 have been used to select a total of 51 virus escape mutants. Crossresistance analysis of the mutants, together with RNA sequencing and identification of amino acid substitutions, have revealed three neutralization sites on the virus surface. Two of these appear to correspond to the NIm-IA and NIm-II sites described for HRV-type 14, although there are also substantial differences. The third site has not been described previously.

show abstract

Section: Introductionmentioning

confidence: 99%

Neutralization epitopes of human rhinovirus type 2

Appleyard

Russell

Clarke

et al. 1990

Journal of General Virology

View full text Add to dashboard Cite

show abstract

“…The human rhinovirus (HRV), identified as the major causative agent of the common cold (Stott & Killington, 1972), is a member of the picornavirus family. The icosahedral protein capsid, which contains the positivestrand genomic RNA, consists of 60 protein trimers made up of three surface structural proteins, VP1, VP2 and VP3 (Mendappa et al, 1971 ;Rueckert, 1976), with a fourth protein, VP4, located internally.…”

mentioning

confidence: 99%

Neutralizing Antibodies to Human Rhinovirus Produced in Laboratory Animals and Humans that Recognize a Linear Sequence from VP2

Hastings

Speller²,

Francis³

1990

Journal of General Virology

View full text Add to dashboard Cite

Synthetic peptides representing amino acids 156 to 170 of virus capsid protein VP2 from human rhinovirus (HRV) type 2 have previously been used to elicit a neutralizing antibody response; polyclonal antisera against this peptide have been compared with a virusneutralizing monoclonal antibody (8F5) which recognizes the same linear sequence. The neutralizing activity of both antibodies against virus is abolished by an amino acid substitution in VP2 at position 163 but only the peptide antiserum neutralizing activity is affected by a change in VP2 at position 158. The minimal binding site of 8F5 has been mapped, using overlapping peptides, to a sequence TRLNPD covering VP2 residues 160 to 165. Using affinity purification it has been shown that 8 to 10% of total neutralizing activity of polyclonal rabbit or guinea-pig antivirus antiserum is due to recognition of this linear VP2 156 to 170 determinant. Furthermore, a similar population of neutralizing antibodies appears to be associated with an immune response to recent HRV infection in humans. These results confirm the existence of linear determinants on the surface of HRV which may be mimicked by suitable synthetic peptides.

show abstract

“…Once in the cell, productive replication may depend on the temperature. Rhinoviruses fail to spread to the lower respiratory tract largely because it is too warm there, their optimum growth being at the lower temperature of the nasal mucosa (22). The state of differentiation of the cell can be a critical factor; this is so for epidermal cells (wart viruses), as well as for neurones, hepatic cells, lymphocytes, or macrophages in the case of other viruses [23,24].…”

Section: A the Virus Must Localize In Respiratory Epitheliummentioning

confidence: 99%

Virology research and virulent human pandemics

Mims

1995

Epidemiol. Infect.

View full text Add to dashboard Cite

SPECIAL ARTICLEVirology research and virulent human pandemics SUMMARY The possibility that a devastating human pandemic could arise, causing massive loss of human life, is discussed. Such a major threat to the human species is likely to be a virus, and would spread by the respiratory route. It need not necessarily cause massive loss of life, but if it caused serious illness or incapacity it would still have a major impact. A possible source is from an existing respiratory pathogen, but it would more probably arise from an infection that is maintained in an arthropod or vertebrate host, but which at present either does not infect humans, or if it does it fails to be effectively transmitted between them. More research should therefore focus on the pathogenetic factors and the viral determinants that promote respiratory transmission.

show abstract

Rhinoviruses

Cited by 64 publications

References 0 publications

Neutralization epitopes of human rhinovirus type 2

Neutralization epitopes of human rhinovirus type 2

Neutralizing Antibodies to Human Rhinovirus Produced in Laboratory Animals and Humans that Recognize a Linear Sequence from VP2

Virology research and virulent human pandemics

Contact Info

Product

Resources

About