Rhinovirus infections

Abstract

Summary One hundred and seventy-five rhinoviruses were isolated from 4·4% of patients in the general practice survey and 44 from 1·8% of children in the hospital survey. Isolations were made at all times of the year and although isolated most frequently from cases of common cold rhinoviruses were also found in association with other respiratory syndromes.

Rhinovirus RNA Polymerase: Products and Kinetics of Appearance in Human Diploid Cells

“…Rhinoviruses form the largest subgroup of the picornaviruses with at least 89 serotypes (5). Though causing predominantly a mild upper respiratory infection, rhinoviruses are also associated with more severe illness of the lower respiratory tract (8). Normal methods of control through immunization are precluded by the number of serotypes so that chemotherapy appears a more likely prospect, and the viral RNA-dependent RNA polymerase is a possible target for chemotherapeutic investigation.…”